A research team led by Associate Professor Yohei Funakoshi, Associate Professor Kimikazu Yakushijin, and Professor Hironobu Minami of the Division of Medical Oncology/Hematology at Kobe University Hospital, together with Associate Professor Goh Ohji of the Division of Infectious Disease Therapeutics and Takaji Matsutani of Anymics Inc., has developed the pGen-SHM plot. The method combines the generation probability (pGen) of individual B-cell receptor (BCR) sequences with somatic hypermutation (SHM) associated with antigen-driven maturation. This enables the visualization and objective assessment of the maturation of the BCR repertoire after allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Researchers led by the University of Osaka analyzed lymphatic malformations from 34 patients and found shared molecular features regardless of whether PIK3CA mutations were detected. The PI3K/AKT/mTOR pathway was activated in malformed lymphatic vessels, while spatial transcriptomics highlighted NFATC1, associated with the calcineurin-NFAT pathway, as a possible contributor to the disease pathogenesis. The findings deepen the understanding of lymphatic malformations and may help refine existing treatments and identify new therapeutic targets.

A new study suggests that therapeutic food made from locally available crops such as chickpeas, sorghum, maize and soybeans could help make malnutrition treatment more affordable and accessible in regions where it is needed most. By reducing reliance on costly imported dairy ingredients, the plant-based formulation could support local production, strengthen agricultural supply chains and help close the global treatment gap. The researchers say the approach could offer a more sustainable model for expanding access to lifesaving nutrition care.

An international survey of more than 1,100 patients, caregivers, healthcare providers and patient advocates found high confidence in plasma-derived medicines and deep gratitude for the donors who make them possible.