A newly developed algorithm shows how a gene is expressed at microscopic resolution
Peer-Reviewed Publication
Updates every hour. Last Updated: 28-Apr-2025 22:08 ET (29-Apr-2025 02:08 GMT/UTC)
Stanford type A aortic dissection (AD) is a degenerative aortic remodeling disease and carries a high mortality rate. It manifests distinct temporal patterns, transiting from acute, subacute to chronic stages. As an intimate pathophysiological feature of AD, aortic inflammation triggers disease initiation and progression. However, the precise subtypes of immune cells, their fundamental functional properties, and crosstalk with vascular cells across disease temporal transition remain largely unexplored. In a paper published in Science Bulletin, Junjie Luo from China Agricultural University, and colleagues analyzed 64,371 single immune cells by scRNA-seq coupled with TCR tracking using STARTRAC to quantitatively delineate the distinct functions and dynamic relationships of aortic immune cells in the context of temporal-specific AD. This study provides a comprehensive evaluation of how the composition of the immune landscape is altered in the aortic wall of diverse types of AD, and opens new avenues for a rational and precise anti-AD therapy by targeting TNF signaling.