Scientists from the University of Nottingham have developed a new method of genetic analysis, which extracts more precise data than previously used methods when looking at DNA, and will improve our understanding of the genetic basis of rare and complex diseases.

The findings of the new study, which are published in Physiological Genomics, explain a new method of analysing genetics, which determines the extent to which genes are involved in phenotype formation.

The previously used method extracted information using averages from different datasets, meaning that it had limitations in terms of the type of information it could provide, and what scientists could learn from it.

The largest trial to examine the impact of colchicine in acute myocardial infarction (MI) found that both acute and long-term colchicine use did not reduce cardiovascular death, myocardial infarction, stroke, or ischemia-driven revascularization.

Findings were reported today at TCT 2024, the annual scientific symposium of the Cardiovascular Research Foundation (CRF). TCT is the world’s premier educational meeting specializing in interventional cardiovascular medicine. 

A research team exploring how genes and environmental factors interact in psychiatry has discovered that a history of sexual trauma and a genetic tendency to develop mental illness are associated with increased risk for schizophrenia, bipolar disorder and major depression. The findings, reported Oct. 30 in the journal JAMA Psychiatry, highlight the importance of evaluating the contributions of social and environmental risk factors in human genetic studies and emphasize the need for routine screening of sexual trauma in clinical settings.