Heart failure is the terminal stage of various cardiovascular diseases, usually characterized by pathological myocardial hypertrophy. So far, the pathogenesis of heart failure is not fully understood. The global burden of cardiovascular disease and epidemiological evidence indicate that in addition to traditional risk factors such as genetic inheritance and hypertension, exposure to exogenous environmental pollutants is a new risk factor. In recent years, the use of antimicrobials has increased, resulting in more exposure of these substances to humans, raising concerns about potential risks to human and environmental health. According to the findings of this study, the exposure to antibacterial agent TCC may be a new risk factor for metabolic cardiovascular diseases. This conclusion is supported by physiological indicator tests and a combined analysis of metabolomics and transcriptomics in cardiac organoids.
