A stem cell pathway offers a new route to periodontal bone regeneration
Peer-Reviewed Publication
Updates every hour. Last Updated: 23-Oct-2026 06:17 ET (23-Oct-2026 10:17 GMT/UTC)
Periodontitis can damage tooth-supporting bone as stem cells lose their regenerative capacity with age. Researchers at Sichuan University found that IGFBP5 reduced cellular senescence and restored bone-forming ability in dental follicle stem cells by modulating WNT5B-related signaling. An engineered hydrogel carrying IGFBP5-overexpressing cells improved periodontal bone regeneration in rats. The findings highlight a potential strategy for rejuvenating therapeutic stem cells and supporting the development of regenerative treatments for age-related periodontal bone loss.
Colouring using phones and tablets was just as effective as using pencils and paper in reducing stress, depression and anxiety in young people.
Study screened children across Germany, UK, Italy, Denmark, Sweden, Czechia, Portugal, Poland
Around 1 in 45 children with a near relative with T1D was found to be in the early stages of the condition, and 1 in 350 children with no relative
Protocol developed by German team could be rolled out across Europe and other countries
Researchers recommend general population screening at age 2–4 years for T1D, if islet antibody-negative again at age 6–8 years and at age 10–15 years for detecting individuals with early-stage type 1 diabetes.
Integrating such screening into other health initiatives should be targeted, this will vary for each country
Children who have never been screened could catch up by joining this schedule at the earliest opportunityVery low carbohydrate (VLC) diets may be associated with health benefits in children with type 1 diabetes (T1D) and were not associated with acute diabetes complications, new research being presented at the annual meeting of the European Association for the Study of Diabetes (EASD) in Milan, Italy (Sept 28 – Oct 2) has found.
Incidence of T1D was increased by 11% in the post-vaccination cohort from September 2014 compared with the pre-vaccination cohort
Study contradicts authors hypothesis that protection from infection would reduce incidence of type 1 diabetes
However additional analyses suggest that the increased incidence of T1D may not be caused by the vaccine and further studies are needed