Scientists discover potential for serious harm from chemical loophole
Peer-Reviewed Publication
Updates every hour. Last Updated: 3-Sep-2025 08:11 ET (3-Sep-2025 12:11 GMT/UTC)
The scientific community has long believed that polymers—very large molecules—are too big to migrate out of products into people and therefore pose no health risks. As a result, polymers have largely evaded regulation. For example, polymers are exempt from the major toxics acts: Toxic Substances Control Act in the U.S. and REACH in the E.U. However, a breakthrough peer-reviewed study published today in Nature Sustainability demonstrates that polymers used as flame retardants can break down into smaller harmful chemicals.
This study investigates the conversion of endothelial cells to osteoblast-like cells and its role in maintaining bone homeostasis. The authors focus on the Kindlin-2/Piezo1/TGFβ/Runx2 signaling pathway, showing that endothelial-to-osteoblast conversion is crucial for bone health. The findings suggest that endothelial cells can adopt osteoblast-like functions, thus contributing to bone maintenance and repair. This conversion process could have therapeutic implications for bone-related diseases, including osteoporosis and fractures, offering new insights into vascular-bone interactions.
A ‘chasm of misunderstanding and miscommunication’ is often experienced between clinicians and patients, leading to autoimmune diseases such as lupus and vasculitis being wrongly diagnosed as psychiatric or psychosomatic conditions, with a profound and lasting impact on patients, researchers have found. A study involving over 3,000 participants – both patients and clinicians – found that these misdiagnoses (sometimes termed “in your head” by patients) were often associated with long term impacts on patients’ physical health and wellbeing and damaged trust in healthcare services.