During therapy, some cancer cells evolve to escape elimination. Newer anticancer drugs that can overcome this resistance are necessary. Now, researchers from Japan demonstrate that aromatic benzaldehyde inhibits the growth of therapy-resistant pancreatic cancer. By preventing various signaling proteins and histone modifiers like Ser²⁸-phosphorylated histone H3 (H3S28ph) from binding to 14-3-3ζ protein, benzaldehyde overcomes therapy resistance and blocks plasticity to prevent the spread of cancer. These findings highlight its potential in cancer treatment.

Delayed complications following stereotactic radiosurgery (SRS) for brain arteriovenous malformations (AVMs) are rare and poorly understood. This case report describes a patient who developed cyst formation ten years after SRS, which later progressed to a chronic encapsulated expanding hematoma (CEEH). The study highlights a likely pathophysiological link between cyst formation and CEEH and emphasizes the importance of complete surgical removal to prevent recurrence and ensure long-term resolution of such late-onset complications.

The pilot work of the 10K Chinese People Genomic Diversity Project (10K_CPGDP) has uncovered a complex genetic admixture landscape and biological adaptations among ethno-linguistically diverse groups in the Silk Road region of China. In this study, 1,207 individuals from four linguistically diverse groups were sequenced or genotyped, and a population split between Northwest Chinese minority ethnic groups and Han Chinese dating back to the Upper Paleolithic period was observed. The research provides new insights into the genetic architecture and adaptative history of these groups, shedding light on their genomic and phenotypic diversity and the complex evolutionary influences on human disease and health.

Scientists have identified a subtype of immune cells that help advanced prostate cancer evade the body’s defenses. In mouse models, blocking a protein produced by those cells made tumors more responsive to immunotherapy, pointing to a potential new treatment approach. The study, with Shenglin Mei of the Fralin Biomedical Research Institute among the corresponding authors, is featured on the July cover of Molecular Cancer Research.

Researchers examine how the use of animal testing to identify endocrine-disrupting substances in the EU can be reduced. Although it is, in principle, possible to identify such substances without using animals, non-animal methods are still rarely applied.

A new AI model is much better than doctors at identifying patients likely to experience cardiac arrest.

The linchpin is the system’s ability to analyze long-underused heart imaging, alongside a full spectrum of medical records, to reveal previously hidden information about a patient’s heart health.