Scripps Research team pioneers an efficient way to stereoselectively add fluorine to drug-like molecules
Peer-Reviewed Publication
Updates every hour. Last Updated: 16-Dec-2025 23:16 ET (17-Dec-2025 04:16 GMT/UTC)
Fluorine is critical for biomedicine. This element can help drug compounds be more potent and last longer in the body, and its radioactive isotope, fluorine-18, powers medical imaging techniques such as positron emission tomography (PET). But scientists have long struggled with adding fluorine to the most common chemical bonds—carbon–hydrogen (C–H) bonds—in a way that’s precise, efficient and compatible with the molecules used to create many modern medicines. There’s been particular interest in constructing carbon–fluorine bonds stereoselectively—that is, attaching fluorine from a specific direction in space to create the needed fluorinated stereoisomer (“mirror image” form) of the target molecule. Stereoselective C–H fluorination has remained one of the most challenging synthetic transformations, and the limited approaches developed to date have relied on expensive specialty chemicals or complicated, multi-step procedures. Now, chemists at Scripps Research have developed a long-sought method to stereoselectively attach fluorine atoms to complex, drug-like molecules in a single step using cheap, readily available fluoride salts.
The SETI Institute’s Artist in Residency (AIR) program announced that American artist Adrien Segal is the recipient of the Planetary Futures Public Art Residency. This research-creation residency invites the artist to collaborate with scientists whose work advances planetary science, with a focus on climate research. By connecting artistic practice with scientific discovery, the residency aims to foster dialogue, raise awareness, and inspire collective action, emphasizing how the study of other planets can provide valuable perspectives to better understand and address climate-related issues here on Earth. This two-year residency includes a $30,000 stipend.
Based in Oakland, CA, Adrien Segal is an internationally exhibited artist with work featured in books, academic journals and galleries around the world. She has participated in numerous Artist Residencies across the US, Canada, and Europe, and has work in permanent collections including the City of Homer, Alaska, the Museum of Art in Wood in Philadelphia, and the National Academy of Science in Washington, D.C. In 2022, Segal was a US-UK Fulbright Scholar with the Duncan of Jordanstone College of Art and Design at the University of Dundee in Scotland. Past appointments include the Latham Fellowship at IIT Institute of Design in Chicago, a Visiting Artist at San Diego State University, Benchspace Cork in Ireland, and the University of Lethbridge in Canada.
"I'm excited to welcome Adrien into the SETI Institute's Artist in Residence program," said Bettina Forget, SETI AIR Program Director. "She weaves together science, landscape, data, and materiality to create cross-disciplinary sculptural works that evoke deep emotional responses and a unique sense of place. I look forward to working with Adrien as she starts diving into the research at the SETI Institute."
A new study published in Planet reveals a Micro-XRD method to quantitatively measure the ancient collision histories of meteorites. Researchers from China, Canada, and Japan have developed a quantitative technique to determine peak shock pressures in enstatite chondrites—rare meteorites chemically linked to Earth’s building blocks—using micro-X-ray diffraction (micro-XRD) method.
New experiments reveal jarosite’s selective bromine capture under Mars-like conditions, offering a fresh lens to decode the Red Planet’s aqueous past and halogen cycling.