Pennington Biomedical Research Center investigates tirzepatide's role in weight loss and metabolic health
Peer-Reviewed Publication
Updates every hour. Last Updated: 24-Apr-2025 19:08 ET (24-Apr-2025 23:08 GMT/UTC)
Researchers at the Pennington Biomedical Research Center conducted a first-of-its-kind study to provide insights into the mechanisms of action of tirzepatide – a drug known as Zepbound™ – on weight loss with respect to energy expenditure, fat oxidation and calorie intake. The study, “Tirzepatide did not impact metabolic adaptation in people with obesity, but increased fat oxidation,” published in Cell Metabolism, showed that tirzepatide decreased participants’ calorie intake at lunch/dinner by reducing appetite while increasing fat oxidation, thus helping participants to lose weight. However, the drug did not decrease the slowing down of their metabolic rate usually observed with weight loss.
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