New research published in Nature Ecology and Evolution reveals significant recent shifts in tree diversity among the tropical forests of the Andes and Amazon, driven by global change.

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Extracellular vesicles (EVs) play pivotal roles in cancer from inception through all phases of development.

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EV-mediated signaling profoundly influences the tumor microenvironment (TME), fostering immune evasion.

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EV-based liquid biopsies are promising when biopsy sampling is challenging.

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Engineered EVs show potential for targeting tumors more precisely.

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The lack of an acceptable and reliable guide for selecting in vitro or in vivo brain metastasis models hinders the development of brain metastasis therapies.

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There is an urgent need to employ accurate in vitro and in vivo models to recapitulate the complexities of brain tumor metastasis and to unravel the intricate cellular and physiological processes involved.

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Precise in vitro and in vivo brain metastasis models are crucial for investigating cellular and molecular mechanisms and serve as preclinical platforms to assess novel treatments.

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An array of emerging techniques, such as bio-three-dimensional (3D) printing, novel real-time imaging, artificial intelligence, and precise gene editing, holds promise for redefining the landscape of cancer brain metastasis model development.