SCALE: a novel framework of educational objectives in the AI era
Peer-Reviewed Publication
Updates every hour. Last Updated: 3-Nov-2025 07:11 ET (3-Nov-2025 12:11 GMT/UTC)
The era of AI requires new educational taxonomies that prepare AI natives for personal and professional success. In a new breakthrough, a researcher from the Educational University of Hong Kong has proposed, in TAO, the novel SCALE taxonomy that integrates scientific literacy, computational thinking, AI literacy, learning to learn/metacognition, and engineering and design thinking. It equips AI natives to engage in meaningful experiences and promotes “authentic learning through creating” in the age of AI.
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This study determined cryo-EM structures of midnolin-proteasome complexes, providing mechanistic insights to midnolin-catalyzed substrate degradation. Based on structural and mechanistic understanding, authors have engineered the midnolin system for targeted degradation of desired substrates, and provide the first proof-of-principle for degrading a non-native therapeutically high-profile target that is otherwise undruggable.