Self-propelled protein-based nanomotors for enhanced cancer therapy by inducing ferroptosis
Peer-Reviewed Publication
Updates every hour. Last Updated: 29-Jun-2025 05:10 ET (29-Jun-2025 09:10 GMT/UTC)
The development of ferroptosis-based nanotherapeutics is generally limited by poor penetration depth into tumors and potential systemic toxicity.
In a recent issue of International Journal of Extreme Manufacturing, Tu and coworkers from Southern Medical University addressed these challenges by proposing the design and fabrication of self-propelled ferroptosis nanoinducers, composed of only two endogenous proteins with natural bioactivity.
This work offers a strategy for constructing a biocompatible cancer treatment paradigm with enhanced diffusion to achieve deeper penetration into tumor tissues, centered around the concept of ferroptosis.
The entry of quantum computers into society is currently hindered by their sensitivity to disturbances in the environment. Researchers from Chalmers University of Technology in Sweden, and Aalto University and the University of Helsinki in Finland, now present a new type of exotic quantum material, and a method that uses magnetism to create stability. This breakthrough can make quantum computers significantly more resilient – paving the way for them to be robust enough to tackle quantum calculations in practice.
The new prediction method was tested with satellite remote sensing and species distribution data over 20 years in Andalusia, making possible the development of more dynamic and integrative conservation area prioritisation indicators
A team led by Assistant Professor Gianmarco Mengaldo from the Department of Mechanical Engineering in the College of Design and Engineering at the National University of Singapore (NUS), together with his doctoral student Chenyu Dong and collaborators Dr Davide Faranda (LSCE, France), Assistant Professor Adriano Gualandi (University of Cambridge, UK), and Professor Valerio Lucarini (University of Leicester, UK), has developed a novel method for estimating the predictability of complex dynamical systems.
Because of their desirable properties and low cost, plastics are now found everywhere. Their use has become particularly common in agricultural and food production systems since the 1950s. Against this backdrop, the French Ministry of Agriculture and Food Sovereignty; the French Ministry for the Ecological Transition, Biodiversity, Forests, Marine Affairs and Fisheries; and the French Agency for Ecological Transition (ADEME) asked INRAE and CNRS to conduct a collective scientific assessment focused on the use of plastics in agriculture and food production. The assessment synthesised existing knowledge about plastic uses, properties, and recycling. It also examined the impacts of plastics on human health and the environment. These results were presented at a public conference on May 23.
Current data indicate that 20% of plastic usage in France occurs in the context of agriculture and food production, namely for food packaging. The composition and structure of plastics have grown more complex over time, notably as additives and multiple layers have been employed to achieve specific combinations of properties. The result is plastics that are more difficult to recycle. The collective scientific assessment also underscores the massive degree of microplastic contamination—microplastics are found in all the world’s soils and are particularly abundant in agricultural soils. The latter likely contain more tons of microplastics than do the world’s oceans. Additionally, the bodies of all living organisms, including those of humans, are contaminated by microplastics, a reality with adverse health effects. Finally, the assessment highlights that we need research to boost the adoption of plastic alternatives, simplify plastic composition and structure, and better analyse the needs of agricultural and food industry stakeholders as a means for reducing plastic production.
The development of synthetic apomixis enables the fixation of heterosis, which is a breakthrough that promises to transform conventional hybrid breeding strategies and trigger a new wave of green revolution in agricultural production. At present, the engineered synthetic apomixis system, which is entirely based on genome editing, exhibits reduced fertility, thereby limiting its practical applications. Recently, the research team led by Kejian Wang at the China National Rice Research Institute combined MiMe-related genes with the OsPLDα2 gene through genome editing technology, creating a new apomixis system termed Fix4 (Fixation of hybrids 4). This system not only produces stable and heritable clonal seeds but also shows a normal seed-setting rate, providing theoretical support and innovative solutions for accelerating the application of apomixis technology in hybrid rice production.