Targeting viral enzymes to strengthen brain immunity against HSV-1
Peer-Reviewed Publication
Updates every hour. Last Updated: 30-Jun-2025 13:10 ET (30-Jun-2025 17:10 GMT/UTC)
Herpes simplex virus type 1 (HSV-1) infections can lead to deadly brain inflammation, yet treatment options remain limited. Japanese researchers have now uncovered how HSV-1 evades the host’s intrinsic immunity by using an enzyme, uracil-DNA glycosylase, to block APOBEC1, a host protein that edits viral DNA to suppress infection. They also developed a promising therapeutic strategy to restore immune defense in the brain, offering new hope for managing HSV-1-induced encephalitis.
The University of Colorado Anschutz Medical Campus announced today that its Department of Ophthalmology received a historic $40 million gift to treat and potentially cure eye diseases like macular degeneration and glaucoma, increase focus on basic science, and harness artificial intelligence to revolutionize vision care in the years ahead.
In an increasingly digitized and connected environment, the demand for computer programmers continues to grow and so does the need for training to produce new coding specialists. Often, they are professionals from other sectors who want to switch career path. In these cases, the acquisition of computational thinking and programming skills is of key importance for them to succeed in this process. A study promoted by the Universitat Oberta de Catalunya (UOC) has identified a new teaching resource that can help them achieve this goal: playing certain video games that are available to everyone for pure entertainment.
When fractions of a second make all the difference: Empa researchers developed a process for manufacturing advanced thin films in which sophisticated timing enables high-quality functional layers at low process temperatures. The new method has applications in the semiconductor industry as well as in future quantum and photonics technologies.
To improve individual-level adaptability and parameter fitting stability, the research team led by Dr. Junjie Jiang and Dr. Zigang Huang from the School of Life Science and Technology at Xi'an Jiaotong University conducted extensive simulations using synthetic networks and data. They proposed a novel, generalizable, and adaptive whole-brain dynamic prediction framework. By incorporating personalized initialization strategies, variable learning rates, feature-specific gradient modulation, and an approximate loss function combined with gradient adjustment mechanisms, the model substantially enhanced its ability to reconstruct subject-specific BOLD dynamics. This approach effectively overcomes the convergence and accuracy limitations inherent in traditional modeling techniques.
Dr. Deanna M. Kaplan at Emory University has developed Fabla, a groundbreaking smartphone app that captures voice narratives in participants' daily environments. This innovation addresses critical gaps in understanding how clinical interventions, from psychedelic therapies to meditation practices, affect people's real-world experiences beyond laboratory settings.
With a strong tailwind, the University of Oulu’s 6G Flagship sets a new course as Vice-Director Ari Pouttu steps up to the wheel. He succeeds Professor Matti Latva-aho, who has led the programme since its inception in 2018. Latva-aho has been elected Vice Rector for Research at the University of Oulu and begins his five-year term this July.
At the EuCNC & 6G Summit in Poznań—Europe’s foremost event in the field this year—the University of Oulu unveiled both its new 6G leadership and the tenth issue of 6G Waves. This edition of the magazine highlights research infrastructures and their essential role in international collaboration.