A new collaborative study reveals how an mRNA-based influenza vaccine reshapes immune responses at the cellular and molecular levels. By tracking germinal-center activity and individual secreted antibody clonotypes for up to six months, researchers uncover how vaccination drives the evolution and diversification of immune responses. The findings offer new insights into how mRNA technology could help address a key challenge in influenza prevention: generating broader antibody responses against a constantly evolving virus.

Cancer immunotherapy offers long-term remissions but struggles with primary resistance, complex progression, and severe side effects. A landmark review in Science Bulletin highlights how multimodal AI integrates multi-scale data—from spatial omics and pathology to imaging and health records—to transform patient stratification. Tracing AI's evolution into foundation models and "virtual cells," the authors outline a clinical roadmap balancing efficacy, toxicity, and disease dynamics.

Kyocera Corporation and Tohoku University have developed a new technology that integrates optical isolators directly onto silicon photonics chips using laser annealing. Building on their previous collaboration, the two organizations will continue working toward commercialization and more efficient, sustainable information technologies. 

Understanding how interfacial water governs photocatalytic hydrogen evolution is essential for rational photocatalyst design. Here, we directly characterize the adsorption state and hydrogen-bonding structure of interfacial water and correlate them with hydrogen evolution activity. We reveal that relatively weaker water-TiO₂ interactions and more flexible hydrogen-bond networks favor higher interfacial water reactivity. These findings provide a molecular basis for engineering water-catalyst interfaces to enhance photocatalytic performance.

A novel OsSBEIIb allele was identified in an indica rice mutant. The OsSBEIIb mutation increases the resistant starch (RS) content in raw rice flour, as well as in retrograded and heated rice. The chalk2 mutant serves as a valuable indica rice germplasm for breeding high-RS rice varieties.

An elite germplasm, G253, with superior morphogenic callus induction and proliferation capacity was identified. A stable Agrobacterium-mediated transformation platform enabling transgenic plant generation was established. An efficient protoplast transient transformation system was developed from the morphogenic callus.