Supramolecular self-assembly with dual functions of GSH-synthesis inhibition and consumption for efficient chemodynamic therapy
Peer-Reviewed Publication
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In this system, Fc could convert overexpressed H2O2 to produce ·OH. Importantly, Cur could form dynamic boronate ester bonds with BA, and be encapsulated in SPSAs-1 through responsive chemical bond to form SPSAs-2. The acidic microenvironment and excessive H2O2 within tumor cells cause the dissociation of boronate ester bonds and β-CD/Fc complexes, releasing Cur. As a result, the GSH level could be reduced through the combination of the BA-induced GSH consumption and Cur-induced inhibition of TrxR activation, further enhancing CDT efficacy.
Scientists have developed a groundbreaking on-chip quantum memory platform using 3D-nanoprinted hollow-core waveguides called "light cages" to store flying photons in cesium vapor. This innovative approach achieves storage times of several hundred nanoseconds while enabling multiple quantum memories on a single chip. The technology marks a major advance in spatially multiplexed quantum memories for use in quantum repeaters and photonic quantum computing platforms.