Cancer Dependency Map now includes next-generation 3D cancer models
Peer-Reviewed Publication
Updates every hour. Last Updated: 30-Oct-2026 14:17 ET (30-Oct-2026 18:17 GMT/UTC)
DepMap scientists have generated dependency data on nearly 150 three-dimensional cancer cell models across 10 cancer types.
The updated catalog reveals cancer phenotypes, cell states, and gene dependencies that are missed in traditional cell lines and shows that both model types are complementary because each captures biology that the other misses.
The integration of data on 2D and 3D models creates a more comprehensive DepMap, moving the resource towards its goal of capturing the complete landscape of cancer vulnerabilities.
SUMMARY: The U.S. National Science Foundation National Solar Observatory (NSF NSO) announced today a major breakthrough in solar physics. Using the world's most powerful solar telescope, the NSF Daniel K. Inouye Solar Telescope near the summit of Maui’s Haleakalā, combined with computer simulations, an international team of scientists from the NSO, NSF NCAR High Altitude Observatory (HAO), and the Max Planck Institute for Solar System Research (MPS) found the signature of Kelvin-Helmholtz instability (KHI), tiny swirling patterns like small whirlpools, on the Sun's surface. Researchers suggest that KHI might be a key reason why the Sun's outer atmosphere gets so hot, and why magnetic energy builds up and moves around on the Sun. Magnetic energy fuels solar flares and eruptions—the kind of solar activity that can send bursts of energy toward Earth and affect satellites, power grids, and other technology. The discovery opens a new window into the fundamental physics of the Sun and other stars while underscoring the unmatched capabilities of the Inouye Solar Telescope.
Quasi-one-dimensional (quasi-1D) van der Waals (vdW) materials represent an emerging frontier in nanoscience, yet the synthesis of their metastable phases remains a significant challenge. Now, researchers at Beijing Institute of Technology have developed a kinetically-controlled anion-exchange (KCAE) strategy that, for the first time, produces uniform, wafer-scale (1-inch) films of W6Te6 — a metastable quasi-1D material previously inaccessible by conventional methods. By first converting a tungsten film into a stable WS2 template with vertically aligned grains, then carefully controlling tellurization, the team creates a kinetic barrier that traps the system in the W6Te6 phase, preventing it from racing to the thermodynamically stable WTe2. The method is also compatible with standard photolithography, enabling pre-patterned W6Te6 nanostructures.
Researchers found beneficial shifts in gut microbial activity, adding to the promise of biofortified staple crops as a practical, food-based strategy for improving iron nutrition.