Experimental models for cancer brain metastasis
Chinese Medical Journals Publishing House Co., Ltd.Highlights
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The lack of an acceptable and reliable guide for selecting in vitro or in vivo brain metastasis models hinders the development of brain metastasis therapies.
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There is an urgent need to employ accurate in vitro and in vivo models to recapitulate the complexities of brain tumor metastasis and to unravel the intricate cellular and physiological processes involved.
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Precise in vitro and in vivo brain metastasis models are crucial for investigating cellular and molecular mechanisms and serve as preclinical platforms to assess novel treatments.
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An array of emerging techniques, such as bio-three-dimensional (3D) printing, novel real-time imaging, artificial intelligence, and precise gene editing, holds promise for redefining the landscape of cancer brain metastasis model development.