A cigarette compound-induced tumor microenvironment promotes sorafenib resistance in hepatocellular carcinoma via the 14-3-3η-modified tumor-associated proteome
Peer-Reviewed Publication
Updates every hour. Last Updated: 2-Apr-2026 15:15 ET (2-Apr-2026 19:15 GMT/UTC)
Hepatocellular carcinoma (HCC), characterized by high aggressiveness and recurrence, poses a significant global health challenge. The interplay between the tumour microenvironment and exogenous exposures disrupts homeostasis, and tumour biological behaviours, then accelerating tumour progression. Sorafenib, a first-line targeted therapy, often faces resistance due to tumour heterogeneity and microenvironmental changes. Understanding the link between adverse exposures and drug resistance, identifying key molecules, and developing precise interventions are crucial for improving the management of advanced/drug-resistant HCC.
Climate change and armed conflict rank among the strongest drivers of migration across Africa. A new study by researchers at Chungnam National University analyzes 20 years of data (1995–2015) from African nations, finding that climate adaptation—particularly improvements in agricultural productivity—significantly weakens migration pressures linked to drought and armed conflict. Higher adaptive capacity, including better water access, health systems, and infrastructure, moderates these effects most during overlapping crises.
A new opinion paper argues that proprioception should be redefined beyond a fixed biological feedback loop. The authors propose that proprioception should be better understood as a dynamic, interpretable interface that can be edited, augmented, and potentially surpassed through engineered signals—an idea that could reshape rehabilitation strategies and open new directions for performance enhancement in elite athletes.
Electric vehicles (EVs) represent the next-generation technology aimed at transport decarbonization. Unfortunately, their limited lifespan leaves behind the problem of retired EV battery management. Recently, a Chonnam National University scientist has shed light on the attitude of consumers towards the reuse of retired EV batteries as energy storage systems. They suggest that consumer trust in companies, environmental identity, and innovativeness affects acceptance via perceived risks and benefits and affective responses.