HKUST researchers use vesicle proteomics to reveal novel cargo clients and accessory factors for AP-1 and AP-4
Peer-Reviewed Publication
Updates every hour. Last Updated: 23-Jan-2026 18:11 ET (23-Jan-2026 23:11 GMT/UTC)
The secretory pathway in eukaryotic cells is crucial for maintaining cellular function and physiological activities, as it ensures the accurate transport of proteins to specific subcellular locations or for secretion outside the cell. A research team led by Prof. GUO Yusong from the Division of Life Science at The Hong Kong University of Science and Technology (HKUST) has been extensively investigating the molecular mechanisms by which cargo proteins are recognized and loaded into transport vesicles in the secretory pathway. The team has successfully reconstituted the packaging of multiple disease-related cargo proteins into vesicles along the secretory route, providing a powerful tool for dissecting the molecular mechanisms of cargo loading. In addition, they developed an innovative analysis platform that integrates vesicle reconstitution with electron microscopy and proteomics, enabling systematic identification of vesicle protein composition and morphological features. This comprehensive approach has proven effective in uncovering novel cargo clients and cellular factors that mediate vesicular trafficking (Figure 1).
Recently, a review study led by Professor Xuejun Liu from the College of Resources and Environmental Sciences at China Agricultural University and Tianxiang Hao et al. systematically analyzed the current status of China’s farmland carbon budget, providing a scientific solution to this dilemma. The related paper has been published in Frontiers of Agricultural Science and Engineering (DOI: 10.15302/J-FASE-2025602).
Recently, Guoqin Huang from Jiangxi Agricultural University and Kai Huang from Guangxi Hydraulic Research Institute systematically reviewed the multiple benefits of sugarcane intercropping in optimizing soil fertility. Their findings offer new insights for ecological restoration of dry sloping farmland in southern China. The related paper has been published in Frontiers of Agricultural Science and Engineering (DOI: 10.15302/J-FASE-2025612).
The National Institute of Information and Communications Technology (NICT) and the Nagoya Institute of Technology (NITech), collaborated with the Japan Aerospace Exploration Agency (JAXA), have achieved the world’s first successful demonstration of next-generation error correction codes, mitigating the impact of atmospheric turbulence on ground-to-satellite laser communications.
Atmospheric turbulence in ground-to-satellite laser links is known to cause fading, resulting in burst data errors. Error correction codes are one of the key technologies to mitigate such effects. In this experiment, we transmitted next-generation error correction codes with high correction capability (5G NR LDPC and DVB-S2) and successfully corrected burst data errors caused by atmospheric turbulence in the laser link. This result confirmed that both codes can significantly improve communication quality compared to conventional schemes.
This achievement is expected to contribute to the practical implementation of ground-to-satellite laser communications by applying these codes.