Breakthrough in bidirectional skin-organ crosstalk unveils novel therapeutic avenues for systemic diseases — international team identifies skin as a central hub for systemic inflammation regulation
Peer-Reviewed Publication
Updates every hour. Last Updated: 11-Sep-2025 02:11 ET (11-Sep-2025 06:11 GMT/UTC)
Recently, a paradigm-shifting review published in MedComm-Future Medicine redefines the skin as a “central command center” that orchestrates health across multiple organs. Led by Prof. Ting Li’s team at Macau University of Science and Technology, the study identifies key molecular messengers, particularly the immune protein IL-17A, that derive bidirectional signaling along the newly defined “skin-organ axis”. By combining evidence from clinical trials with advanced microfluidic organ-chip models, this work proposes a roadmap for revolutionary therapies targeting systemic diseases from arthritis to depression.
Statisticians from the National University of Singapore (NUS) have developed a pioneering approach for analysing population-scale metabolomic data, marking a major advancement in the precision and depth of metabolic profiling. This new method promises to improve both personalised healthcare and preventive medicine by improving the accuracy and interpretability of metabolic analyses.
Mass General Brigham researchers are shining a powerful new light into the viral darkness with the development of Luminescence CAscade-based Sensor (LUCAS), a rapid, portable, highly-sensitive diagnostic tool for processing complex biological samples. Compared to its diagnostic predecessors, LUCAS creates 500-fold stronger and 8-fold longer-lasting bioluminescence signals, overcoming longstanding challenges faced by point-of-care diagnostics. Their study published today in Nature Biomedical Engineering.
A research team sheds light on the intricate regulatory mechanisms governing anthocyanin biosynthesis in horticultural plants, offering insights that could enhance plant traits and agricultural productivity.
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