Sugar-coated nanotherapy dramatically improves neuron survival in Alzheimer’s model
Peer-Reviewed Publication
Updates every hour. Last Updated: 4-Sep-2025 09:11 ET (4-Sep-2025 13:11 GMT/UTC)
In many neurodegenerative diseases, proteins misfold and clump together in brain tissue. Scientists developed a new therapy made of peptides and a sugar that naturally occurs in plants. The therapeutic molecules self-assemble into nanofibers, which bond to the neuron-killing proteins. Now trapped, the toxic proteins can no longer enter neurons and instead harmlessly degrade.
When biting into a chili pepper, you expect a fiery sensation on your tongue. This spiciness is detected because of capsaicinoid compounds. But for some peppers, despite high levels of capsaicinoids, the heat is mysteriously dull. Now, researchers reporting in ACS’ Journal of Agricultural and Food Chemistry have identified three compounds that lessen peppers’ pungency. These results challenge the reliability of the century-old Scoville scale, which traditionally bases its rating on two capsaicinoids.
A new study published in the journal Environmental Science & Technology examined associations between diet, drinking water, and “legacy” PFAS—chemicals that were phased out of production in the US in the 2000s—with blood samples from California residents. PFAS exposure was associated with consumption of seafood, eggs, and brown rice, but fewer other foods than suggested by earlier studies. PFAS levels were elevated among people who lived in areas where these chemicals were detectable in their drinking water supply, but lower than levels found in highly contaminated communities.
Researchers at the University of the Basque Country (EHU) have explored how a combination of photovoltaic energy and heat pumps could be used to carry out the energy retrofitting of social rental housing. The Basque Government’s Zero Plan was used as the basis, and the technologies that the European Union is keen to promote were assessed. The buildings in Araba-Álava were generally found to offer the greatest potential for implementing the system.
After its new extension, which increased its computing power fourfold, the Jean Zay supercomputer is now capable of 125.9 million billion operations per second. Hosted and operated by the CNRS’s Institute for Development and Resources in Intensive Scientific Computing (IDRIS), Jean Zay, which was acquired by the French Grand Équipement National de Calcul Intensif (GENCI), has become one of France’s most powerful supercomputers. The official inauguration of this extension, which was announced by the French President, was held on Tuesday, 13 May 2025.
Researchers in Japan have developed a digital laboratory (dLab) system that fully automates the material synthesis and structural, physical property evaluation of thin-film samples. With dLab, the team can autonomously synthesize thin-film samples and measure their material properties. The team’s dLab system demonstrates advanced automatic and autonomous material synthesis for data- and robot-driven materials science.