An engineering team at Jiangxi Normal University, in collaboration with South China University of Technology, reports an entropy-driven strategy to construct low-topology-entropy silicone elastomers (LTE-SEs) in the journal Wearable Electronics. The materials achieve ultra-softness and ultra-high stretchability while maintaining high strength, and are successfully applied in skin-conformal flexible encapsulation, UV-protection patches, and fully encapsulated safety-positioning insoles, providing a new generation of substrate materials for long-term, comfortable, and reliable wearable electronics.