This study presents a novel method to produce genetically modified rats by generating functional rat sperm in germ cell-deficient mice via blastocyst complementation with rat ES cells. Fluorescent rat ES cell lines were established, validated for pluripotency, and used to generate rat sperm in chimeric mice. The sperm successfully fertilized rat oocytes, producing viable offspring. This technique bypasses traditional chimera generation and reduces cost, offering an efficient platform for complex rat genetic engineering using ES cells.

Australian scientists have successfully developed a research system that uses ‘biological artificial intelligence’ to design and evolve molecules with new or improved functions directly in mammal cells. The researchers said this system provides a powerful new tool that will help scientists develop more specific and effective research tools or gene therapies.

Bladder cancer often becomes resistant to standard treatments due to its ability to evade apoptosis, the primary form of cell death targeted by conventional therapies. In a recent study, researchers from China developed a nanomedicine that triggers ferroptosis—a different cell death pathway—without needing external activation. Their proposed system not only killed resistant cancer cells but also enhanced the immune system's anti-tumor response, offering a promising dual-action therapy for bladder cancers.

POSTECH and Linyi University develop ‘SLY,’ a Probe That Glows Yellow Only in Tumor Cells.