Brain “stars” hold the power to preserve cognitive function in model of Alzheimer’s disease
Peer-Reviewed Publication
Updates every hour. Last Updated: 4-Apr-2026 00:15 ET (4-Apr-2026 04:15 GMT/UTC)
Excessive screen use among school-aged children has been linked to sleep disturbances and behavioral problems, but its effects on brain development have remained unclear. Now, researchers from Japan have examined data from over 11,000 children to explore the relationship between screen time, attention-deficit/hyperactivity disorder (ADHD) symptoms, and brain structure. Their findings reveal that longer daily screen exposure is linked to increased ADHD symptoms and measurable changes in brain development.
A research team led by Professor Eijiro Miyako at the Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology (JAIST), has discovered that the marine bacterium Photobacterium angustum demonstrates remarkable therapeutic efficacy against colorectal cancer.
Through screening of multiple marine bacterial strains, the researchers found that P. angustum, in its natural, non-engineered form, selectively accumulates in tumor tissues and induces both direct tumor lysis and robust immune activation. In mouse models, intravenously administered P. angustum showed high tumor tropism while exhibiting minimal colonization of vital organs except the liver, with no hematological abnormalities or histological toxicity observed.
Furthermore, P. angustum therapy promoted intratumoral infiltration of immune cells including T cells, B cells, and neutrophils, and enhanced production of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). The bacterium also demonstrated intrinsic oncolytic activity through natural exotoxin production, directly destroying cancer cells. These combined mechanisms significantly prolonged survival in treated mice, with complete remission achieved in some cases.
This research represents a critical advance toward developing safer, more biocompatible cancer immunotherapies that do not rely on genetically modified organisms (GMOs).
The study has been accepted for publication in the Journal for ImmunoTherapy of Cancer, a leading international journal in the field of cancer immunotherapy.
Dr. Jongkil Park and his team of the Semiconductor Technology Research Center at the Korea Institute of Science and Technology (KIST) have presented a new approach that mimics the brain's learning principles. The team engineered the principle of spike-timing-dependent plasticity (STDP), in which the brain adjusts the strength of connections based on the order of signal firing between neurons. This allows them to learn the connectivity in a brain's neural network in real-time without having to store the activity of all the neurons.
Wearable sensors integrated with deep learning techniques have the potential to revolutionize seamless human–machine interfaces for real-time health monitoring, clinical diagnosis, and robotic applications. Nevertheless, it remains a critical challenge to simultaneously achieve desirable mechanical and electrical performance along with biocompatibility, adhesion, self-healing, and environmental robustness with excellent sensing metrics. Herein, we report a multifunctional, anti–freezing, self-adhesive, and self-healable organogel pressure sensor composed of cobalt nanoparticle encapsulated nitrogen-doped carbon nanotubes (CoN CNT) embedded in a polyvinyl alcohol–gelatin (PVA/GLE) matrix. Fabricated using a binary solvent system of water and ethylene glycol (EG), the CoN CNT/PVA/GLE organogel exhibits excellent flexibility, biocompatibility, and temperature tolerance with remarkable environmental stability. Electrochemical impedance spectroscopy confirms near-stable performance across a broad humidity range (40%-95% RH). Freeze-tolerant conductivity under sub-zero conditions (−20 °C) is attributed to the synergistic role of CoN CNT and EG, preserving mobility and network integrity. The CoN CNT/PVA/GLE organogel sensor exhibits high sensitivity of 5.75 kPa−1 in the detection range from 0 to 20 kPa, ideal for subtle biomechanical motion detection. A smart human–machine interface for English letter recognition using deep learning achieved 98% accuracy. The organogel sensor utility was extended to detect human gestures like finger bending, wrist motion, and throat vibration during speech.
As emerging two-dimensional (2D) materials, carbides and nitrides (MXenes) could be solid solutions or organized structures made up of multi-atomic layers. With remarkable and adjustable electrical, optical, mechanical, and electrochemical characteristics, MXenes have shown great potential in brain-inspired neuromorphic computing electronics, including neuromorphic gas sensors, pressure sensors and photodetectors. This paper provides a forward-looking review of the research progress regarding MXenes in the neuromorphic sensing domain and discussed the critical challenges that need to be resolved. Key bottlenecks such as insufficient long-term stability under environmental exposure, high costs, scalability limitations in large-scale production, and mechanical mismatch in wearable integration hinder their practical deployment. Furthermore, unresolved issues like interfacial compatibility in heterostructures and energy inefficiency in neuromorphic signal conversion demand urgent attention. The review offers insights into future research directions enhance the fundamental understanding of MXene properties and promote further integration into neuromorphic computing applications through the convergence with various emerging technologies.
Lithium-ion batteries (LIBs), while dominant in energy storage due to high energy density and cycling stability, suffer from severe capacity decay, rate capability degradation, and lithium dendrite formation under low-temperature (LT) operation. Therefore, a more comprehensive and systematic understanding of LIB behavior at LT is urgently required. This review article comprehensively reviews recent advancements in electrolyte engineering strategies aimed at improving the low-temperature operational capabilities of LIBs. The study methodically examines critical performance-limiting mechanisms through fundamental analysis of four primary challenges: insufficient ionic conductivity under cryogenic conditions, kinetically hindered charge transfer processes, Li⁺ transport limitations across the solid-electrolyte interphase (SEI), and uncontrolled lithium dendrite growth. The work elaborates on innovative optimization approaches encompassing lithium salt molecular design with tailored dissociation characteristics, solvent matrix optimization through dielectric constant and viscosity regulation, interfacial engineering additives for constructing low-impedance SEI layers, and gel-polymer composite electrolyte systems. Notably, particular emphasis is placed on emerging machine learning-guided electrolyte formulation strategies that enable high-throughput virtual screening of constituent combinations and prediction of structure–property relationships. These artificial intelligence-assisted rational design frameworks demonstrate significant potential for accelerating the development of next-generation LT electrolytes by establishing quantitative composition-performance correlations through advanced data-driven methodologies.