Clinical study of gene therapy for GM2 gangliosidosis, including Tay-Sachs disease, shows encouraging results

Avoiding the formation of unwanted clusters of similar elements when dividing data into groups is of great importance for the analysis of medical data. Psychologists and computer scientists from Heinrich Heine University Düsseldorf (HHU) developed a new method to solve this “anticlustering” problem in 2020. Together with researchers from the University of California, San Francisco (UCSF), they have now developed an extension, which is important for analysis of high-throughput sequencing data and more. The researchers describe their new tool in the context of an application to the chronic disease endometriosis in the scientific journal Cell Reports Methods.

Researchers have identified key factors that influence the flavour of chocolate during the cocoa bean fermentation process, a discovery that could offer chocolate producers a powerful tool to craft consistently high-quality, flavour-rich chocolate.

Researchers have developed a self-powered microneedle patch to monitor a range of health biomarkers without drawing blood or relying on batteries or external devices. In proof-of-concept testing with synthetic skin, the researchers demonstrated that the patches could collect biomarker samples over periods ranging from 15 minutes to 24 hours.

Farmers in Arkansas, Louisiana and Mississippi, pay four to six times more for crop insurance than their counterparts in the upper Midwest, and Hunter Biram wanted to know why. The result of his research with colleagues in Kansas was published in late July in the American Journal of Agricultural Economics.

SAN ANTONIO — August 18, 2025 — Southwest Research Institute (SwRI) has developed and tested a micrometeoroid and orbital debris (MMOD) detection and characterization system designed for satellites and spacecraft to monitor impacts from space debris. The system provides critical post-impact data, ensuring awareness of an impact even when damage is not immediately apparent.

Inspired by the serrated stinger of a honeybee,  a new microneedle platform was developed in International Journal of Extreme Manufacturing (IF: 21.3) to combine drug delivery, electrical stimulation, and continuous monitoring in a single, wearable system. This platform tackles one of the toughest problems in modern medicine: diabetic wound healing.