Deep-penetration light-triggered pyroptosis based on nanomedicine for tumor precision therapy still remains challenging. Towards this goal, Scientist in China reported a supramolecular engineering strategy to construct Pt(IV)-coordinated supra-(carbon dots) with NIR-activated photocatalytic capacity to trigger tumor pyroptosis, thereby evoking anti-tumor immune responses to suppress distant tumor and prevent cancer metastasis. The finding will open new avenues for precision phototherapy in future clinical oncology by supramolecular-mediated nanomedicine with deep-penetration light triggered pyroptosis.

Boracycles are important functional scaffolds, finding increasing applications in catalysis, synthesis, materials science, and pharmaceuticals. However, current studies predominantly focus on three-, five-, and six-membered boracycles, leaving four-membered boracycles largely unexplored. A research team led by Prof. QUAN Yangjian and Prof. LIN Zhenyang from the Department of Chemistry at the Hong Kong University of Science and Technology (HKUST), in collaboration with Prof. LYU Hairong from The Chinese University of Hong Kong (CUHK), has made a breakthrough in developing an efficient synthetic approach to four-membered boracycles. This advancement enables the facile synthesis of other previously inaccessible boracycles, which may lead to valuable applications.