Making the ‘invisible’ visible: How high-speed movies could change the way scientists study disease
Peer-Reviewed Publication
Updates every hour. Last Updated: 26-Oct-2026 13:17 ET (26-Oct-2026 17:17 GMT/UTC)
High-speed movies of microscopic worms may sound like a dull night at the cinema, but this advanced imaging capability could help scientists better understand how diseases begin and progress, track subtle changes in cells and study how the body responds to treatments.
A new study reveals that exposing dwarf spiders to a brief period of warm temperatures can disrupt a phenomenon where internal bacteria normally force genetic males to develop as females. Surprisingly, this reproductive disruption skips the directly heated spiders and hits their children and grandchildren instead, leading to a sudden comeback of male offspring. The temporary heat scrambles the spiders' internal microscopic ecosystem, allowing a rival bacterium to surge ahead and block the feminizing bacteria from taking over.
New research finds that birds can use lactate, often thought of as a metabolic waste product, as a cellular fuel that aids in rapid recovery from a harmful state that impairs oxygen delivery. Haemoglobin, the protein that carries oxygen to our tissues, naturally converts to methaemoglobin, which limits the blood’s oxygen-carrying capacity. This research shows how bird red blood cells (RBCs) can use lactate to rapidly resurrect blood function, and they can do this better than mammals because they contain mitochondria — the “powerhouses of the cell” — something that mature mammalian RBCs do not possess.
Researchers at the University of Colorado Anschutz have developed a promising nonhormonal therapy for women experiencing Genitourinary Syndrome of Menopause (GSM). GSM is a common chronic condition caused by declining estrogen levels that affects the vulva, vagina and urinary tract, leading to symptoms such as vaginal dryness, painful intercourse, and recurrent vaginal and urinary tract infections.
Unlike over-the-counter treatments that may provide some temporary symptom relief, the new therapy is designed to restore estrogen signaling only within vaginal tissue, without exposing the rest of the body to estrogen.
In a preclinical animal study, the treatment restored the structure and function of vaginal tissue lost through estrogen deficiency, suggesting a potential way to address the underlying cause of GSM rather than simply managing its symptoms.
The findings were published today in Menopause.
“For too many women, the current options are either products that only provide temporary relief or hormone-based treatments they may not feel comfortable using,” said the paper’s senior author Steve Nordeen, PhD, professor emeritus, department of pathology at the CU Anschutz School of Medicine.
An estimated 50% to 70% of women experiencing natural or medically induced menopause develop one or more symptoms of GSM.