The BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine has gone in this seventeenth edition to Daniel Joshua Drucker (Mount Sinai Hospital, Toronto, Canada), Joel Habener (Harvard University, United States), Jens Juul Holst (University of Copenhagen, Denmark) and Svetlana Mojsov (The Rockefeller University, United States) for fundamental biological discoveries that have driven the development of new generation drugs against diabetes and obesity.