A new study from researchers at The University of Texas MD Anderson Cancer Center finds that, in healthy women, some breast cells that otherwise appear normal may contain chromosome abnormalities typically associated with invasive breast cancer. The findings question conventional thinking on the genetic origins of breast cancer, which could influence early cancer detection methods.

The study, published today in Nature, discovered that at least 3% of normal cells from breast tissue in 49 healthy women contain a gain or loss of chromosomes, a condition known as aneuploidy, and that they expand and accumulate with age. This poses questions for our understanding of “normal” tissues, according to principal investigator Nicholas Navin, Ph.D., chair of Systems Biology.

November 20, 2024 – Genome Research (https://genome.org) publishes a special issue highlighting advances in long-read sequencing applications in biology and medicine. In this first of two Special Issues guest-edited by Dr. Ana Conesa, Dr. Alexander Hoischen, and Dr. Fritz Sedlazeck, Genome Research publishes a diverse collection of research and review articles highlighting novel applications and developments in long-read sequencing (LRS). Papers in this issue focus on original research offering novel biological and clinical insights gained using long-read DNA and RNA sequencing technologies and other long molecule approaches. The issue offers significant advances in long-read sequencing analysis, including novel methods for genome assembly and annotation, characterization of complex structural variation, quantifying DNA and RNA modification, full-length mRNA isoform resolution, vaccine and gene therapy vector quality control, and bacterial outbreak tracing. Several of the studies are highlighted below. 

Typically, closely related animal species have difficulty coexisting because they are competing for similar resources. Despite eating the same figs, binturong, small-toothed palm, masked palm, and common palm civets do coexist together. To understand how they coexist, a new study explores their degree of faunivory.