Adipose tissues, which serve as fat reserves, have been recognized as an endocrine organ. The three-dimensional (3D) bioprinting of adipose tissues has potential applications in regenerative medicine. However, the 3D bioprinting conditions have not been optimized for adipose tissues. Now, researchers from Korea have developed a novel method for 3D adipose tissue bioprinting using a hybrid bioink. The 3D bioprinted adipose tissues exhibited skin regeneration ability, paving the way for their applications in regenerative medicine.

Chinese scientists from Prof. ZHOU Jianmin's team at the Institute of Genetics and Developmental Biology revealed that a widespread plant defense metabolite may help combat bacterial diseases in crops.

　How did mammalian faces evolve from reptilian ones? Our study describes the morphological details of mouse craniofacial development, challenging the view that mammals and reptiles share the same jaw structure pattern. We show that mammals lost a reptile-like ancestral jawbone, reorganizing their upper jaw and transforming the ancestral jaw tip into an independent nose. These findings enhance our understanding of facial evolution and provide new insights into human craniofacial development and disorders.

This study investigates the conversion of endothelial cells to osteoblast-like cells and its role in maintaining bone homeostasis. The authors focus on the Kindlin-2/Piezo1/TGFβ/Runx2 signaling pathway, showing that endothelial-to-osteoblast conversion is crucial for bone health. The findings suggest that endothelial cells can adopt osteoblast-like functions, thus contributing to bone maintenance and repair. This conversion process could have therapeutic implications for bone-related diseases, including osteoporosis and fractures, offering new insights into vascular-bone interactions.

Why retinoic acid is effective in this setting but not against primary tumors, has been speculated about for nearly 50 years. St. Jude Children’s Research Hospital scientists resolved the mystery, showing the drug “hijacks” a normal developmental pathway to trigger cancer cell death.

A team of researchers at Rice has developed an innovative AI-enabled, low-cost device that will make flow cytometry ⎯ a technique used to analyze cells or particles in a fluid using a laser beam ⎯ affordable and accessible.