Prolonged nutrient deprivation drives motif-specific DNA methylation changes in Flavobacterium columnare, a major fish pathogen. Using advanced Nanopore sequencing, researchers found that specific methylation patterns—especially demethylation of a 6mA-modified motif—serve as epigenetic signatures of starvation adaptation. Temperature also influences these changes. The findings reveal a novel survival mechanism in bacteria and provide a valuable methodological reference for bacterial epigenetics.

Few among us appreciate being called cheap, yet this term has a useful application in bird world. A new study published in the Journal of Raptor Research, “Factors Influencing Nestling Sex Ratios of Suburban and Rural Red-Shouldered Hawks, 2004-2016,” finds that male Red-shouldered Hawks (Buteo lineatus) are the cheaper of the sexes, meaning hawk parents prioritize producing female offspring when conditions are optimal. This means that higher quality territories could result in more females, offering biologists clues about habitat health, which is important intel as the species adapts to urban environments with increasing frequency. 

Researchers in Japan found that lower plasma copper levels and reduced white matter volume in individuals with autism spectrum disorder were associated with clinical symptom scores, including social symptom severity. Using a mouse model, they show that developmental copper deficiency disrupts brain vascular and metabolic signaling, impairs oligodendrocyte maturation and myelination, and alters social behavior through mitophagy and mTOR suppression.

As global climate change intensifies and agricultural environments become increasingly arid, understanding the adaptive mechanisms of terrestrial plants is critical for global food security. Plant cuticular wax forms a vital hydrophobic barrier that protects crops from severe water loss, UV radiation, and pathogen infection. Sorghum (Sorghum bicolor (L.) Moench), a major drought-tolerant crop, is valued for its thick cuticular wax layer, which markedly enhances resilience to abiotic stresses. However, the key regulatory mechanisms governing cuticular wax accumulation and very-long-chain fatty acid (VLCFA) biosynthesis have remained largely uncharacterized.