Obesity disrupts “reaction time” to starvation in mice
Peer-Reviewed Publication
Updates every hour. Last Updated: 25-Apr-2025 09:08 ET (25-Apr-2025 13:08 GMT/UTC)
Researchers led by Keigo Morita and Shinya Kuroda of the University of Tokyo have revealed a temporal disruption in the metabolism of obese mice when adapting to starvation despite no significant structural disruptions in the molecular network. This is a breakthrough discovery as research including the temporal dimension in biology has been notoriously laborious and extracting systematic insight from big data has been difficult. Thus, this study paves the way for further research into more general metabolic processes, such as food intake and disease progression. The findings were published in the journal Science Signaling.
Expecting feedback from an avatar compared to a real human facilitates risk-taking behavior in a gambling task, and a brain region called the amygdala is central to this facilitation, according to a study published April 22nd in the open-access journal PLOS Biology by Toshiko Tanaka and Masahiko Haruno from the National Institute of Information and Communications Technology, Japan.
Dopamine is the brain’s motivational spark, driving us to chase what feels good, say scrolling another reel on social media, and steer clear of what doesn’t, like touching a hot stove. But scientists haven’t fully understood how dopamine helps us learn to avoid bad outcomes — until now.
A new study from Northwestern University shows that dopamine signals in two key brain areas involved in motivation and learning respond differently to negative experiences, helping the brain adapt based on whether a situation is predictable or controllable.
While previous research has shown that dopamine can respond to negative experiences, this is the first study to track how those signals evolve over time as animals move from novices to experts in avoiding them.