Robot-assisted radical prostatectomy (RARP) has become the standard treatment for localized prostate cancer. However, postoperative urinary incontinence and erectile dysfunction remain common complications. A new review published in UroPrecision systematically examines nerve-sparing techniques during RARP, including anatomical foundations, surgical planes, innovative approaches, and patient selection tools, providing a practical guide for balancing cancer control and functional preservation.

To better understand how environmental conditions may have shaped the development of millet agriculture, researchers from the Institute of Earth Environment of the Chinese Academy of Sciences, and their collaborators in and aboard China investigated loess deposits from the Chinese Loess Plateau (CLP).

An international, interdisciplinary team of researchers led by Göttingen University has been awarded a Human Frontiers Science Program (HFSP) research grant for the project “Noise or signal? Information fidelity at the edge of jamming”. The award is worth 1.2 million dollars for 3 years. Together with academics from New York University and Hokkaido University in the US and Japan, the funding will enable the development of innovative and international training and exchange of expertise, methods and new materials. This will support an interdisciplinary team of researchers to investigate the biophysical properties of biological and synthetic materials and develop ways to measure and understand signalling within cell materials.

Adequate boron (B) supply is essential for optimal growth and yield formation in rapeseed (Brassica napus L.). With boron-deficient soils affecting croplands worldwide, developing varieties with enhanced boron-use efficiency represents a sustainable strategy to safeguard productivity. Central to this effort is the identification of genes that regulate boron homeostasis. 

Artificial intelligence can dramatically speed up the painstaking work of tracking wildlife with remote cameras, cutting analysis time from months or even a year to just days while producing nearly the same scientific conclusions as humans. That’s according to a new study led by researchers at Washington State University and Google, published in the Journal of Applied Ecology. The team tested whether a fully automated AI system could replace humans in processing hundreds of thousands to millions of camera trap images collected in Washington, Montana’s Glacier National Park, and Guatemala’s Maya Biosphere Reserve.

High concentrations of free fatty acid (FFA) in ketotic dairy cows activate endoplasmic reticulum (ER) stress pathways, contributing to mammary epithelial cell apoptosis and reduced milk yield. The study sets the stage for in vivo trials to validate ER stress inhibitors like Tauroursodeoxycholate (TUDCA) as practical solutions for managing ketosis and enhancing dairy cows health.

A research team from the School of Biomedical Sciences at the LKS Faculty of Medicine, the University of Hong Kong (HKUMed), has uncovered the mechanism underlying how cancer patients respond to a widely used cancer drug, known as paclitaxel, offering insights that may help overcome cancer drug resistance. The study found that small differences in microtubules, the structures inside cells that help the cells divide and move, can determine the efficacy of paclitaxel. This finding was published in Nature Chemical Biology.

Kyoto, Japan -- A hallmark of Type 2 diabetes is the progressive loss of beta cell mass: cells in the pancreas that produce and release insulin.  The endoplasmic reticulum stress response, a cellular pathway that maintains protein homeostasis, plays a critical role in beta cell function and survival, and the protein ATF6α is one of the key regulators of this stress response. However, the significance of ATF6α signaling in the stress-adaptive regulation of beta cell mass has remained unclear, prompting a team of researchers at Kyoto University to investigate.

"Our previous single-cell RNA-sequencing data suggested transient ATF6α upregulation during adaptive beta-cell proliferation, which sparked our interest in its potential role," says first author Daisuke Otani.

The team generated mice lacking ATF6α, specifically in beta cells. They assessed beta cell mass, proliferation and apoptosis, or cell death, of the mice under chronic stress conditions, including high-fat diet and pregnancy. The team also performed complementary in vitro experiments using chronically stressed beta cell lines, and single-cell RNA sequencing using the high-fat diet model.