Throwing a ‘spanner in the works’ of our cells’ machinery could help fight cancer, fatty liver disease… and hair loss
Peer-Reviewed Publication
Updates every hour. Last Updated: 28-Apr-2025 08:08 ET (28-Apr-2025 12:08 GMT/UTC)
Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the ‘powerhouses’ of our cells, allows us to make the fuel we need from sugars, a process vital to all life on Earth. Scientists at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out the structure of this machine and shown how it operates like the lock on a canal to transport pyruvate – a molecule generated in the body from the breakdown of sugars – into our mitochondria.
Lehigh University Senior Research Scientist Arup K. SenGupta, a professor emeritus in the Department of Civil and Environmental Engineering, is the 2025 recipient of the Simon W. Freese Environmental Engineering Award and Lecture, presented by the American Society of Civil Engineers (ASCE). SenGupta, an ASCE Fellow, is an internationally recognized water scientist whose research has led to sustainable solutions for removing arsenic, fluoride, and other contaminants from drinking water around the world. His pioneering work in ion exchange science has also advanced technologies for desalination, wastewater reclamation, and carbon capture.
Cambridge, MA, April 18— Insilico Medicine(“Insilico”), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, is proud to announce Pharma.AI Day 2025, the brand-new quarterly update series for Pharma.AI, scheduled on April 24, 10:00-11:00 AM EST. Register here to join Alex Zhavoronkov PhD, Founder and CEO of Insilico Medicine, and get a deep dive into a series of AI breakthroughs and new product demos.
An international research team led by Mayukh Kumar Ray, Mingxuan Fu, and Satoru Nakatsuji from the University of Tokyo, along with Collin Broholm from Johns Hopkins University, has discovered the anomalous Hall effect in a collinear antiferromagnet. More strikingly, the anomalous Hall effect emerges from a non-Fermi liquid state, in which electrons do not interact according to conventional models. The discovery not only challenges the textbook framework for interpreting the anomalous Hall effect but also widens the range of antiferromagnets useful for information technologies. The findings were published in the journal Nature Communications.
To address the limitations of contemporary lithium-ion batteries, particularly their low energy density and safety concerns, all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming alternative. Among the various SEs, organic–inorganic composite solid electrolytes (OICSEs) that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale applications. However, OICSEs still face many challenges in practical applications, such as low ionic conductivity and poor interfacial stability, which severely limit their applications. This review provides a comprehensive overview of recent research advancements in OICSEs. Specifically, the influence of inorganic fillers on the main functional parameters of OICSEs, including ionic conductivity, Li+ transfer number, mechanical strength, electrochemical stability, electronic conductivity, and thermal stability are systematically discussed. The lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic perspective. Besides, the classic inorganic filler types, including both inert and active fillers, are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of OICSEs. Finally, the advanced characterization techniques relevant to OICSEs are summarized, and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.
POSTECH-KIER research team develops high-power, high-energy-density anode using nano-sized tin particles and hard carbon.