Single shot multispectral fluorescence microscopy with learned meta-optics
Peer-Reviewed Publication
Updates every hour. Last Updated: 27-Oct-2026 07:16 ET (27-Oct-2026 11:16 GMT/UTC)
High numerical aperture fluorescence microscopy can reveal fine biological detail, yet its shallow depth of field makes thick multicolor samples challenging to image without axial scanning. Researchers developed MANTIS, a single shot computational microscope that combines a learned meta-optic with neural reconstruction to generate sharp multispectral fluorescence images in samples up to 50 micrometers thick at NA 1.1. The method expands imaging depth and suppresses defocus blur, enabling clearer visualization of thick biological samples.
Professor Dr Gert Aarts is known for his work on strongly interacting matter and for linking theoretical physics with machine learning. Wübben Stiftung Wissenschaft is funding Professor Gert Aarts’ appointment as Professor of Theoretical Physics at Bielefeld University with 1.58 million Euros over four years. Aarts assumes the position in August.
High-speed optical imaging is often limited by the trade-off between sensitivity and response speed. Researchers developed an NbSe2/WSe2 semimetal-semiconductor heterostructure that tailors interfacial energy barriers through band engineering, enabling low dark current, rapid photoresponse, and high-fidelity imaging
A research team has developed an interphase activator strategy to improve lithium-ion transport in garnet-polymer composite solid electrolytes. The strategy uses SbF3 to reconstruct the surface of LLZTO garnet particles and regulate the surrounding PVDF-based polymer phase, creating a continuous pathway for lithium ions across the ceramic-polymer interface. The optimized electrolyte shows high lithium-ion conductivity, stable lithium-metal cycling, and strong full-cell performance at 30 ℃, highlighting its promise for safer and higher-energy solid-state lithium-metal batteries.
This perspective article proposes a paradigm shift from single-discipline pathogen control to an integrated, cross-disciplinary approach that combines earth science and environmental engineering. Led by Zheng-Yang Huo from Renmin University of China, an research team outlines how geochemical insights and advanced disinfection technologies can work together to achieve full-chain assessment and control of waterborne pathogens, addressing a persistent threat that causes over 10 million deaths annually worldwide.
Mechanical force redistributes reactivity through anisotropic, topology-dependent load transmission. Predicting which covalent bond in a complex molecule ruptures first under tension remains a central problem in mechanochemistry, biomaterials and chemically recyclable polymers. Bond dissociation energy is an incomplete proxy because it describes zero-force thermodynamic stability, whereas mechanochemical site selectivity is governed more directly by the peak force sustained along a prescribed loading path. Here we introduce covalent-bond peak force network (CBPFNet), a graph-attention model that predicts covalent-bond peak force (CBPForce) from relaxed molecular structures through a virtual-stretching workflow and avoids the hundreds of constrained geometry optimisations typically required for each candidate bond. In the CHON benchmark studied here, CBPFNet reproduces bond-ranking trends from density functional theory (DFT) and can be used for bond-level screening. Post hoc attribution analyses indicate that rupture selectivity depends on both bond identity and local stiffness contrast, with relatively rigid segments concentrating tensile stress on softer adjacent bonds. In oligopeptides, the model recovers the DFT weakest bond and highlights a serine-containing motif as a possible topology-dependent weak point under the same protocol. CBPFNet therefore extends screening beyond equilibrium bond stability toward bond-resolved peak-force ranking in sustainable polymer design and biomaterials.
We have theoretically elucidated the molecular-level mechanism by which lithium ions migrate within organic ionic plastic crystals, which are attracting attention as solid electrolytes for next-generation batteries. We verified the "paddlewheel mechanism"--which has been regarded as the primary mechanism of ion conduction for over 25 years--using molecular dynamics simulations and hopping function analysis. The results showed that while the "paddlewheel mechanism" was related to the movement of large ions constituting the crystal, it had almost no correlation with lithium-ion movement; instead, lithium-ion movement is governed by the cooperative rearrangement of "ion cages" formed by surrounding anions. These findings provide new guidelines for designing safe, high-performance solid electrolytes for next-generation batteries at the molecular level.