The research team led by Professor Jichuan Kang has elucidated the regulatory mechanism of AICAR biosynthesis in endophytic Fusarium solani.
Peer-Reviewed Publication
Updates every hour. Last Updated: 11-Sep-2025 06:11 ET (11-Sep-2025 10:11 GMT/UTC)
Endogenous AICAR (Acadesine) demonstrates significant therapeutic potential as a phase III clinical agent for the treatment of adverse cardiovascular reactions to coronary artery bypass grafting and as a phase I/II clinical agent for chronic lymphocytic leukemia. However, its biosynthetic mechanism remains poorly defined. Previous study demonstrated that AICAR was significantly enriched in the Fusarium solani mutant veAOE14, which overexpressed the global regulator VeA. In May 2025, the research team led by Professor Jichuan Kang from the Engineering and Research Center for Southwest Biopharmaceutical Resource of National Education Ministry of China, Guizhou University, published a research paper titled “MtfA, a C2H2 transcriptional regulator, negatively regulates PRPS2-mediated biosynthesis of the adenosine analogue Acadesine in Fusarium solani” in the journal Mycology.
This study elucidated, at the molecular level, the regulatory mechanism by which VeA overexpression enhances AICAR production in Fusarium solani. The team established a three-tier regulatory network model (VeA-MtfA-PRPS2) (Figure 1), laying an important foundation for the engineering of filamentous fungal strains for AICAR biosynthesis.
Tufts University has signed a memorandum of understanding with Indian Institute of Science to establish a framework for the development of a range of possible initiatives jointly pursued by the two institutions.
Abstract
Purpose – This study investigates the causal relationship and mechanisms between the development of digital finance and household carbon emissions. Its objective is to explore how digital finance can influence the carbon footprint at the household level, aiming to contribute to the broader understanding of financial innovations' environmental impacts.
Design/methodology/approach – The research combines macro and micro data, employing input-output analysis to utilize data from the China Household Finance Survey (CHFS) for the years 2013, 2015, 2017, and 2019, national input-output tables, and Energy Statistical Yearbooks. This approach calculated CO2 emissions at the household level, including the growth rate of household carbon emissions and per capita emissions. It further integrates the Peking University Digital Financial Inclusion Index of China (PKU-DFIIC) for 2012–2018 and corresponding urban economic data, resulting in panel data for 7,191 households across 151 cities over four years. A fixed effects model was employed to examine the impact of digital finance development on household carbon emissions.
Findings – The findings reveal that digital finance significantly lowers household carbon emissions. Further investigation shows that digital transformation, consumption structure upgrades, and improved household financial literacy enhance the restraining effect of digital finance on carbon emissions. Heterogeneity analysis indicates that this mitigating effect is more pronounced in households during the nurturing phase, those using convenient payment methods, small-scale, and urban households. Sub-index tests suggest that the broadening coverage and deepening usage of digital finance primarily drive its impact on reducing household carbon emissions.
Practical implications – The paper recommends that China should continue to strengthen the layout of digital infrastructure, leverage the advantages of digital finance, promote digital financial education, and facilitate household-level carbon emission management to support the achievement of China's dual carbon goals.
Originality/value – The originality of this paper lies in its detailed examination of the carbon reduction effects of digital finance at the micro (household) level. Unlike previous studies on carbon emissions that focused on absolute emissions, this research investigates the marginal impact of digital finance on relative increases in emissions. This method provides a robust assessment of the net effects of digital finance and offers a novel perspective for examining household carbon reduction measures. The study underscores the importance of considering heterogeneity when formulating targeted policies for households with different characteristics.
A new collaboration involving the University of Ottawa takes a focused look at a recently developed patient toolkit designed to be a hub for opioid-related resources that’s not only helping optimize therapeutic outcomes but also represents a paradigm shift about how projects like this should be undertaken.
The University of Tennessee Institute of Agriculture dean of AgResearch, Hongwei Xin, has been awarded the Excellence in Leadership Award from agInnovation South, the coalition of directors of state agricultural experiment stations in Southern states. The group is a regional coalition of the national Association for Public and Land-grant Universities (APLU).
At the UT Institute of Agriculture, Xin is responsible for the research programs of approximately 530 agricultural and natural resource faculty and professional scientists that study disciplines spanning seven academic departments and one School of Natural Resources from agricultural and resource economics to plant sciences, animal sciences, and biosystems engineering and soil sciences. Xin also oversees the management of ten research and education centers that conduct field research, demonstrations and education programs in strategic locations across Tennessee.