Recently, the research group led by Dr. Dechao Feng, Lecturer at University College London (UCL) and Distinguished Research Fellow at Zhejiang Provincial People’s Hospital, published a review entitled “Intratumoral Androgens and Genetic Variants Driving Therapy Resistance in Prostate Cancer”. Aligned with the paradigm shift toward precision medicine and individualized management in prostate cancer, this review systematically summarizes the adaptive changes in intratumoral androgen metabolism and androgen receptor (AR) signaling during disease progression from hormone-sensitive prostate cancer (HSPC) to castration-resistant prostate cancer (CRPC) and the highly aggressive subtypes (DNPC and NEPC) emerging during castration resistance, along with research advances in how these mechanisms contribute to therapy resistance. Furthermore, the review critically analyzes current challenges in studying prostate cancer resistance, and outlines future directions toward high-throughput, refined, and personalized strategies, emphasizing the integration of multi-omics technologies and novel in vitro and in vivo models to advance mechanistic insights into drug resistance, thereby establishing a scientific foundation for optimizing individualized therapeutic approaches.

Diabetic foot ulcers can remain open for weeks or months, leaving patients at risk of infection, hospitalization, and amputation.

Underwater landslides are a destructive force, putting vital submarine infrastructure at serious risk and can even generate damaging tsunamis. By analyzing research completed from 2000 to 2025, scientists tracked this phenomenon to better understand what triggers the landslides, how they move and generate tsunamis, and the dangers they pose.

A novel sprayable nanozyme dressing developed by Chinese researchers effectively treats aerobic vaginitis by combining antibacterial, anti-inflammatory, and microbiome-regulating properties. Tested in mice, the dressing not only alleviated infection and inflammation but also restored reproductive function and pregnancy rates, offering a promising non-antibiotic strategy for gynecological care.

Electronic devices capable of perceiving and responding to environmental changes are essential for applications in human–machine interaction, monitoring systems, and robotics. However, most existing devices suffer from the separation of sensing and actuation, leading to complex integration and limited responsiveness. In this study, the researchers introduce an intelligent thermoelectric device inspired by the interplay between sensory and muscle cells in sea anemones. The device seamlessly combines multimodal sensing with autonomous thermal actuation, enabling a closed-loop sensory–motor reflex. It demonstrates excellent temperature sensitivity (0.2 ℃) and pressure resolution (0.03 mm), owing to its three-dimensional architecture and hierarchical conductive network. Molecular dynamics simulations show that its dynamic hydrogen-bonding network enhances stress dissipation and interfacial adhesion, resulting in exceptional mechanical stability over 140,000 cycles. Furthermore, the device exhibits thermal self-adaptation, actively initiating a protection mechanism through thermoresponsive deformation to avoid high-temperature stimuli, with an adjustable actuation threshold. This work represents a significant advancement toward intelligent electronics capable of real-time decision-making and active environmental interaction.

Harvesting low-grade heat from both human metabolism and environmental waste through thermoelectric fabrics offers a sustainable pathway for wearable power generation. However, a critical challenge exists in establishing substantial temperature differentials for continuous thermoelectric generation while maintaining physiologically comfortable skin temperatures in dynamically variable environments.

With the quick development of flexible electronic devices such as foldable phones and wearable sensors, the demand for high-performance flexible transparent conductors (TCs) surges. Thin films of indium tin oxide (ITO), the traditional TCs, are increasingly constrained by their brittleness, limited indium sources, and high fabrication cost. The researchers at Hunan University and Xiamen University, China, have developed a supersaturation modulation strategy, enabling the efficient synthesis of ultra-long silver nanowires (Ag NWs) with high yield. The synthesized Ag NWs exhibit exceptional electrical conductivity, optical transparency, and mechanical flexibility, offering a promising alternative to ITO for next-generation TCs.

Triggering the anionic redox reactions at high voltage is an effective approach to boost the capacity of Li-rich layered oxides. However, the irreversible lattice oxygen release at high voltage and sluggish ion kinetics remain conundrums. Herein, a surface modifying coupling defect engineering strategy is proposed to improve the reversibility of anionic redox reactions and ion diffusion efficiency in Li-rich layered oxides. A LiNbO3 surface modification acts as an effective physical barrier to suppresses lattice oxygen release, thereby improving cycling stability of Li-rich layered oxide. Further, the oxygen vacancies in the LiNbO3 coating enhances the ion transport kinetics, strengthening rate capability. After 500 cycles, a high capacity retention of 83.3% can be achieved for the obtained cathode materials (CV-LLO) at 5 C, much higher than that of the pristine materials (LLO, 52.3%). Moreover, CV-LLO delivers a capacity of 169.9 mAh g-1 at 5 C, which was 65.1% of the capacity at 0.2 C, much higher than that of the pristine LLO (85.6 mAh g-1, 33.7%). This study provides insights into the construction of Li-rich layered oxide cathode with highly reversible anionic redox reaction and highly cycling stability for Lithium storage.