Article Highlights
Updates every hour. Last Updated: 5-Jul-2025 17:10 ET (5-Jul-2025 21:10 GMT/UTC)
Alveolar macrophage cell surface receptor TREM2 promotes lung fibrosis
University of Alabama at BirminghamMonocyte-derived alveolar macrophages, or Mo-AMs, have been identified as key drivers of lung fibrosis disease, but the mechanisms of their pro-fibrotic behavior and survival in the lungs remained unclear. Researchers now show that TREM2, a cell surface receptor protein on Mo-AM cells, is a key mediator in this pathology and a valuable target for developing strategies to neutralize the pro-fibrotic effect of these macrophages.
- Journal
- Nature Communications
Cell sheet production efficiency greatly influenced by polymer brush lengths and densities
Hiroshima UniversityCell sheet preparation for use in tissue engineering and regenerative therapies could be significantly improved with the use of thermo-responsive polymer brushes, adjusted in length and density according to specific cell types
- Journal
- Biomaterials Science
- Funder
- Japan Society for the Promotion of Science, Precise Measurement Technology Promotion Foundation, Casio Science Promotion Foundation
All-in-one smart nanomaterial for cancer diagnosis, treatment, and immune response induction
National Research Council of Science & TechnologyThe Korea Research Institute of Standards and Science (KRISS, President Lee Ho Seong) has successfully developed a nanomaterial* capable of simultaneously performing cancer diagnosis, treatment, and immune response induction.
- Journal
- Chemical Engineering Journal
- Funder
- Ministry of Science and ICT
Do progesterone administration methods affect offspring development?
Shanghai Jiao Tong University Journal CenterProgesterone (P4) is the optimal agent for luteal support in assisted reproductive technologies. Despite the availability of various formulations, the impacts of P4 treatment administered through different routes on offspring growth remain unevaluated. This study aimed to investigate and compare the effects of P4 administration through three different routes in pregnant rats during the teratogenesis-sensitive period on fertility outcomes and the behavior, plasma P4 and pregnenolone levels, and alterations in gut microbiota in the filial generation (F1) of offspring.
- Journal
- Reproductive and Developmental Medicine
Common drugs suppress endometriosis by downregulating lncRNA H19
Shanghai Jiao Tong University Journal CenterAccording to the previous studies, it has been found that long non-coding RNA H19 (lncRNA H19)-ITGB3-miR-124-3p axis can regulate cell proliferation and invasion of the ectopic endometrium, which could be the potential pathway for treating endometriosis by a key medicine. The aim of this study was to investigate the roles of metformin, aspirin, artemisinin, and berberine in regulating the expression of lncRNA H19 in ectopic endometrial stromal cells (ecESCs) and explore novel medicines for the treatment of endometriosis.
- Journal
- Reproductive and Developmental Medicine
Deep learning framework predicts crack propagation in composite materials
Higher Education PressThis article introduces Crack-Net, a deep learning framework that efficiently predicts crack propagation and stress–strain curves in particulate composites. It leverages implicit constraints to enhance accuracy and reduce data needs, offering a practical solution for fracture prediction in complex materials.
- Journal
- Engineering
Sustainable urban water management: A comprehensive strategy for decarbonization
Higher Education PressDiscover how integrating decentralized water systems, source separation, and low-carbon technologies can transform urban water management. This comprehensive strategy aims to reduce carbon emissions while promoting resource conservation and recovery, offering a sustainable approach to meet global climate goals.
- Journal
- Engineering
Real-time damage detection in structural health monitoring via reinforcement learning
Higher Education PressA novel real-time automated damage detection method leveraging reinforcement learning has been unveiled in a recent study published in Engineering. The research, spearheaded by Chengwen Zhang, Qing Chun, and Yijie Lin from Southeast University, China, introduces an innovative approach that significantly enhances the efficiency and accuracy of damage detection in structural health monitoring (SHM) systems, particularly for architectural heritage.
- Journal
- Engineering
Advancing sustainable cement: Enhancing early-age strength in limestone calcined clay cements
Higher Education PressThis article explores technological approaches to enhance the early-age strength of limestone calcined clay cements (LC3), a sustainable alternative to traditional Portland cement. The study examines physical, chemical, and hybrid methods to address the slower strength gain rate of LC3 cements, providing insights for sustainable development in the cement industry.
- Journal
- Engineering