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Updates every hour. Last Updated: 26-Jun-2025 04:10 ET (26-Jun-2025 08:10 GMT/UTC)
Chiral drugs: The future of precision medicine
Shanghai Jiao Tong University Journal CenterChirality is one of the essential attributes of nature. Chiral drugs refer to a class of drugs containing chiral centers, and the molecular stereo-structures of their enantiomers are non-superimposable mirror images of each other. Sixty percent of commonly used drugs, including those from traditional Chinese medicine (TCM), are chiral. Developing a single enantiomer with high efficiency and low toxicity has drawn considerable attention due to significant differences in pharmacological activities, metabolic processes, and toxicity exhibited by the enantiomers of chiral drugs. This review concisely summarizes chiral drugs, including their sources, absolute configuration identification, pharmacological applications, and future research trends, particularly in TCM.
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- LabMed Discovery
Rosmarinic acid shows strong potential as antiviral agent against dengue virus in computational study
Shanghai Jiao Tong University Journal CenterSince the early 20th century, viral infections such as SARS, dengue fever, AIDS, Ebola, influenza and herpes have been among the most common causes of illness and death worldwide. These viruses multiply quickly and lead to epidemics and pandemics. Unfortunately, no drug has been proven to be therapeutically effective in treating or preventing dengue fever. The focus of the review is on computational approaches such as molecular docking and simulation methods to evaluate the stability, inhibition mechanisms and binding interactions of rosmarinic acid (RA) against dengue virus proteins. Based on computational studies, it can be concluded that RA could hinder the spread of dengue virus due to its significant binding and docking affinities with its proteins. Due to its anti-inflammatory properties, broad-spectrum antiviral activity, and desirable low-toxicity pharmacokinetic profile, it is also a viable drug for further experimental validation. The review concludes by discussing how to interpret the in silico data, the shortcomings of the computational method, and the need for further experimental validation to fully explore the potential of RA as a treatment option for dengue.
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- LabMed Discovery
Effects of nanofertilizers on the mechanism of photosynthetic efficiency in plants.
FAR Publishing LimitedNano-fertilizers present a revolutionary advancement over conventional fertilizers, offering significant benefits such as controlled release, efficient use of nutrients, and less pollution. Nano-fertilizers can promote photosynthesis in plants, improve the photosynthetic efficiency of crops, increase the biomass of plants, thereby increasing crop yields through their special physiochemical properties. Nanotechnology as a cutting-edge innovation in agriculture and represent a promising and cost-effective alternative to conventional fertilizers for increasing the productivity of the world's food supply.
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- Phyton
Expanding human control: A review of bilateral teleoperation methods in the robotic era
FAR Publishing LimitedCovering a decade of research, this review dissects how engineers build force-feedback bilateral teleoperation, mapping four channel architectures and seven control algorithms—passivity, energy-bounding, model-predictive and more—each aimed at stability and transparency despite network delays. It spotlights emerging themes such as AI-adaptive gains and multimodal haptics, and ends by sketching frontier scenarios—from remote radioactive handling to dexterous robotic microsurgery—that will stretch the next generation of designs.
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- Computer Modeling in Engineering & Sciences
Healthier rice seedlings and less bakanae disease with paclobutrazol treatment
FAR Publishing LimitedIn a pioneering study, researchers treated rice seeds with various concentrations of paclobutrazol prior to planting, aiming not only to enhance seedling growth but also to reduce the incidence of bakanae disease in rice
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- Phyton
International research team evaluates 30 years of miRNA research in HBV-HCC
FAR Publishing LimitedThirty years on, miRNA-based diagnostic and therapeutic agents for HCC remain a work-in-progress (WIP) and no current miRNA HCC clinical trial has progressed to phase 4. The question remains why this is the case after 30 years and what is the way forward. The major findings and contribution of this paper are that it illustrates the complexity of the miRNA interactome in HBV-HCC in all cellular processes.
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- BIOCELL
Researchers use tree bark wastes to reduce radar detection.
FAR Publishing LimitedResearchers have developed a new flexible material that can attenuate radar signals using tree bark waste as core raw source. The innovative material combines silicone rubber with sustainable carbon derived from tree bark, resulting in an eco-friendly alternative to traditional, high-cost technologies. Despite being made from natural waste, the new material can perform just as well as expensive nanocarbons, offering a greener and more affordable option to attenuate electromagnetic signals.
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- JOURNAL OF RENEWABLE MATERIALS
Circular RNAs in breast cancer diagnosis, treatment and prognosis
FAR Publishing LimitedThis study reviews the most recent studies about the biosynthesis and characteristics of circRNAs in diagnosis, treatment and prognosis evaluation, as well as the value of circRNAs in clinical applications as biomarkers or therapeutic targets in breast cancer. Understanding the mechanisms by which circRNAs function could help transform basic research into clinical applications and facilitate the development of novel circRNA-based therapeutic strategies for breast cancer treatment.
Scientists use heterocycles to target cancer toward safer, smarter treatments
FAR Publishing LimitedThe way a drug works and what it targets in the body are key factors in how effectively it can kill harmful cells. This work looks at a group of important proteins called receptor tyrosine kinases, which are often involved in diseases like cancer. Scientists have found that certain chemical structures—called heterocycles, such as pyrimidine, thiazole, imidazole, indole, acridone, and triazine—can be used to make drugs that target these proteins. With some changes, these compounds could also be designed to affect other disease pathways in the future.