Recently, the researchers identified two distinct subpopulations of mitral/tufted (M/T) cells within the OB that project to the anterior piriform cortex (aPC) and entorhinal cortex (EC). These neural circuits mediate cognitive memory processes through specific-frequency neural coherence. Their discovery not only offers a potential biomarker for cognitive function assessment in PD, but also highlights a candidate therapeutic target for mitigating cognitive decline.

By unraveling the complex choreography of cellular machinery, Michigan State University researchers are helping identify the next generation of drug targets and cancer therapies.

Led by Jian Hu and Kennie Merz, the MSU team has unveiled new insights into a family of proteins that, while vital for cellular functions, are also linked to an array of diseases such as breast, ovarian and pancreatic cancers.

Understanding these dynamic proteins found in cell membranes — called Zrt-/Irt-like proteins, or ZIPs for short — will contribute to the search for cutting-edge drug therapies and the improved health of patients.

Information on the survival of urothelial cancer (UCa) patients with brain metastases (BM) is largely unreliable due to the rarity of such cases. Previous studies that have attempted to capture the prevalence and survival of these patients are limited to case series and retrospective studies with small cohort sizes. This study aimed to explore patient characteristics and treatment outcomes based on treatment modalities from a large sample of patients with UCa and BM.