The immunosuppressive tumor microenvironment (TME) limits immunotherapy efficacy in intrahepatic cholangiocarcinoma (ICC). Understanding the molecular drivers of this TME is essential for developing new therapies. This study aimed to identify novel oncogenes that modulate the immune landscape of ICC using a multi-omics approach.

An international team of researchers, clinicians, educators, ethicists, and patient partners has developed and validated the Health CARE-AI (Contextual, Accountable, Responsible, and Equitable Artificial Intelligence) Framework. Published in JMIR Medical Education, the landmark study provides an actionable, consensus-backed roadmap for the responsible integration of AI across the health care learning and practice continuum.

Immunothrombosis, the interplay between immune activation and coagulation, contributes to disease progression in inflammatory disorders. Its role in hepatitis B virus–related acute-on-chronic liver failure (HBV-ACLF) and the involvement of neutrophil extracellular traps (NETs) remain unclear. This study aimed to elucidate NETs-mediated immunothrombosis in HBV-ACLF.

Koç University researchers have developed a conservation method that combines photogrammetry, digital modeling, 3D printing and embedded sensors to replace missing sections of archaeological amphorae. The customized fills can help monitor environmental and physical changes affecting the artifacts, offering a reproducible approach to their conservation and long-term preservation.

In a paper published in SCIENCE CHINA Earth Sciences, a team of researchers developed new adaptive localization methods for all-sky infrared radiance assimilation. By better accounting for the vertical structure of cloud-related processes and dynamically adjusting localization parameters under different cloud conditions, the new methods significantly improve priors of model state variables and enhance forecasts of tropical cyclone track and intensity. The study provides a new technical pathway for effective use of cloud-affected satellite radiances in an ensemble Kalman filter.

The impact of obesity on brain ageing and the risk of dementia has long been a concern in the medical community. In clinical practice, body mass index (BMI) is commonly used as an assessment indicator, but it does not accurately reflect differences in fat accumulation across various body regions. A recent study by The Hong Kong Polytechnic University (PolyU) has revealed that fat distribution in specific body regions is significantly and distinctly associated with brain structure and cognitive function. In particular, visceral fat was found to accelerate brain ageing and lead to cognitive decline, having more detrimental impact on brain health than any other type of fat.

A research team led by Dr. Seo, Jae hwa at Korea Electrotechnology Research Institute (KERI) Advanced Semiconductor Research Center, working with Professor Yoon, Young jun’s team at Gyeongkuk National University, has achieved Korea’s first demonstration of a silicon carbide (SiC)-based betavoltaic cell designed to generate electricity for more than 50 years without recharging or replacement even in extreme environments such as space and the polar regions. The findings have drawn international attention, having been published in the International Journal of Energy Research, a leading global journal in the energy field ranked in the top 3.6% by JCR and second in its subject category.

Nitrilases are critical industrial biocatalysts for converting nitriles into high-value carboxylic acids, yet their application is often hindered by the formation of insoluble inclusion bodies during heterologous expression. A new study introduces a robust engineering strategy utilizing superfolder green fluorescent protein (sfGFP) fusion to screen for solubility-enhancing mutations. By targeting surface hydrophobic residues, researchers successfully developed a triple mutant, PD1Mut3, which exhibits significantly improved soluble yield, thermostability, and catalytic efficiency, offering a generalizable platform for optimizing enzyme production.

Apple Valsa canker, caused by the fungus Valsa mali, ranks among the most destructive diseases threatening global apple production.