POSTECH researchers develop a bio-implant with virtually no immune response at the cellular and tissue level.

To investigate the role of KIF13B in SICD, a research team led by Prof. Xunde Xian from Peking University conducted a series of experiments using mouse models of sepsis and cultured cardiomyocytes.

Impaired mitophagy and the accumulation of damaged mitochondria are key drivers of endothelial cell (EC) dysfunction in diabetic wounds. While mitochondrial transplantation (MT) has demonstrated therapeuticpotential in such mitochondrial damage-related diseases, its application is still thwarted by elusive mechanisms and practical hurdles such as poor targeting specificity and low delivery efficiency. Here, wereveal that MT acts by reactivating mitophagy to selectively eliminate dysfunctional mitochondria, therebyrestoring mitochondrial homeostasis and rescuing EC functionality. To exploit this discovery, we engineer abiomimetic MT strategy through coating EC-derived apoptotic vesicle membrane (AVM) onto the surfaceof isolated mitochondria. The resulting mitochondria–AVM complex (Mito-AVM) leverages homologoustargeting and phosphatidylserine-mediated “eat-me” signaling, achieving a remarkable 150% increasein delivery efficiency to ECs in diabetic wounds. Furthermore, we construct a 3-aminophenylboric acid-modified hyaluronic acid/polyvinyl alcohol hydrogel for the diabetic wound microenvironment, enablingreactive oxygen species/glucose-triggered sustained release of encapsulated Mito-AVM at the wound site. In summary, our work elucidates a fundamental mechanism of MT and provides an efficient and targetedstrategy for MT therapy, offering fresh perspectives for diabetic wound treatment.

The research findings have been published in Research under the title "Apoptotic Vesicle Membrane-Mediated Targeted Endothelial Mitochondrial Transplantation-Clearance Therapy for Diabetic Wound Healing."

Allergen immunotherapy is entering the era of precision medicine. Instead of treating all allergy patients according to the same scheme, doctors can now tailor therapy to an individual’s molecular allergy profile and specific disease mechanisms. Thanks to modern diagnostics and biomarkers, it is becoming possible to distinguish true allergy from cross-reactivity, better predict treatment effectiveness, and improve patient safety. According to Prof. Marek Jutel from Wroclaw Medical University, allergology is moving toward highly personalized causal treatment, although wider implementation still requires further research, standardization, and broader access to advanced diagnostics.

New report from the Partnership for International Vaccine Initiatives Finds Countries with Seasonal Influenza Programs Achieved 2.5× Higher COVID-19 Vaccination Coverage

Protecting old-growth forests significantly boosts soil physical–biochemical quality, dissolved organic matter chemodiversity, and beneficial mycorrhizal fungi, offering a proven pathway to safeguard endangered Ocotea porosa and mitigate climate change.

Chatbots can provide fast, clear answers about symptoms, and a study from Wroclaw Medical University shows they are usually correct. The problem isn’t obvious errors, but partially accurate answers that sound convincing while missing key clinical details.

In conditions like urinary tract stones—where treatment depends on many factors—such simplifications can mislead patients, delay care, or lead to risky self-treatment.

AI can help patients understand a problem and prepare for a doctor’s visit. But it cannot replace medical consultation, where information is assessed in full clinical context.