Researchers have developed a modular chemoenzymatic platform that efficiently produces six major bioactive alkaloids from Coptidis Rhizoma (Huanglian), a cornerstone of traditional Chinese medicine. Published in Systems Microbiology and Biomanufacturing, the approach combines engineered enzymes with a simple chemical step to overcome longstanding bottlenecks in heterologous biosynthesis and chemical synthesis, achieving gram-scale preparation with yields up to 48%.

A small, nest-dwelling tick found across large parts of Texas could play an outsized role in how the United States responds to African swine fever (ASF) should the virus reach domestic or wild pigs.

In a recent study, researchers at the Texas A&M College of Veterinary Medicine and Biomedical Sciences (VMBS), Texas A&M AgriLife Research and the Department of Biology mapped where Ornithodoros turicata — a soft tick species native to Texas and the southwestern United States — is most likely to survive and examined what that means for ASF preparedness.

The study is part of a $1.4 million Department of Homeland Security-funded research project through the Cross-Border Threat Screening and Supply Chain Defense (CBTS), DHS Science and Technology Directorate (S&T) Center of Excellence housed at Texas A&M. Led by Dr. Meriam Saleh, a clinical assistant professor in VMBS’ Department of Veterinary Pathobiology, this project seeks to understand whether Texas-derived populations of the tick could help sustain or transmit the virus if it were introduced into the U.S. — and how that risk could affect the food supply, trade and cross-border livestock movement. By supporting research at the intersection of animal health, border security and supply chain resilience, CBTS helps address emerging transboundary threats before they escalate into large-scale economic or homeland security challenges.

Fatigue is physical and mental exhaustion that can often be an early sign of severe health conditions. Current treatments for fatigue are mostly behavioral, including light physical activity, improved diet, stress reduction, and rest. Researchers are studying additional ways to manage fatigue, including supplements and enriched foods.