About the Study: Adopting a permissive MAP target resulted in no significant difference in mortality and duration of invasive ventilation at 30 days compared with usual care.

Low-dose aspirin was associated with a 70 per cent lower risk of dementia among 1 in 5 older people with a particular genetic profile, raising the possibility of a more personalised approach to dementia prevention.

A national survey of Ukrainian residents provides one of the clearest estimates to date of the psychological impact of the ongoing war.

UCLA Health is set to participate in a new three-year initiative to expand employment opportunities and training for Californians with intellectual and developmental disabilities — a population that has historically been overlooked by the job market.

New research to be presented at the Annual Meeting of The European Association for the Study of Diabetes (EASD) in Milan, Italy (Sept 28 – Oct 2) shows no link between semaglutide use and pancreatic cancer using nationwide registry data from Denmark, Sweden and Norway. This regulator-mandated post authorisation study, funded by Novo, the manufacturer of semaglutide, is presented by Professor Anton Pottegård, University of Southern Denmark, Odense, Denmark, and colleagues.

Greater variation in blood pressure between research visits was associated with a higher risk of death in a study of more than 57,000 UK Biobank participants. Variation in some blood pressure measures was also associated with strokes, the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Milan, Italy (Sept 28 – Oct 2) heard.

Researchers at Pebble Biotechnology Laboratories have mapped every drug studied in small-rodent models of physical trauma between 1980 and 2020 against its regulatory outcome in humans. Across 5,033 studies and 333 drugs, no new trauma medicine reached approval as a result of that work. A companion systematic review in PLOS ONE reports that 3 of 83 drugs tested in rodent acute injury models achieved first-in-class approval for the tested indication.

A randomized clinical trial found that supervised physical therapy after anterior cruciate ligament (ACL) surgery) yielded greater improvements in pain, function, and muscle strength compared to a self-directed exercise program, at least in the short term.