Call grows to individualize fluid therapy in septic shock
Peer-Reviewed Publication
Updates every hour. Last Updated: 2-Nov-2025 20:11 ET (3-Nov-2025 01:11 GMT/UTC)
Septic shock, a life-threatening complication of infection, has long been treated with rapid infusion of at least 30 mL/kg of intravenous fluids within three hours. But mounting evidence suggests this “one-size-fits-all” approach may harm some patients without benefiting others. An editorial by critical care specialists reviews the science and argues for individualized, dynamically reassessed fluid resuscitation instead of a rigid target. The piece reflects growing calls to update international guidelines.
A recent study published in National Science Review has introduced a policy-specific assessment framework featuring a novel Synergy Index, designed to uncover how air pollution control and carbon mitigation can move in harmony or fall out of step. Drawing on China’s on-road transportation sector as a case study, the research quantifies both the realized and untapped synergies in reducing greenhouse gases (GHGs) and improving air quality. The findings paint a compelling picture: from 2010 to 2020, China’s on-road transportation emission control policies achieved lower GHG emissions, cleaner air, and substantial public health benefits. However, behind this progress lies an unexpected finding showing that policy synergies have been weakening, highlighting the urgency of robust structural transitions to maintain long-term carbon and air-pollution co-control, to advance a sustainable pathway toward the Sustainable Development Goals, and to fullfil the newly announced NDC target.
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