Bronchiolitis obliterans syndrome (BOS) is a common complication in lung transplant patients. While molecular and pathological features have been well characterized, the influence of genetic factors on BOS development remains unexplored. Researchers from Pusan National University compared genetic variations in patient-derived lung tissues and found that the FCGBP gene is associated with BOS development and poor transplant outcomes, thereby, highlighting its role as a potential biomarker to predict transplant outcomes.

In a paper published in National Science Review, the team of Pro. Liu present an innovative computational framework, the sample-perturbed Gaussian graphical model (sPGGM), designed to analyse disease progression and identify pre-disease stages at the specific sample/cell level based on optimal transport theory and Gaussian graphical models. The proposed sPGGM provides a new single-sample way to identify the pre-disease state and discover signaling molecules leading to potential disease, which showcases exceptional effectiveness and robustness for both bulk and single-cell data analyses, offering a novel perspective for personalized disease prediction.

Brain aneurysm is the leading cause of brain hemorrhages. To combat the growing cases of brain aneurysms in China, researchers are conducting a large-scale, national clinical study to evaluate the best surgical and endovascular treatments for unruptured brain aneurysms. The China Treatment Trial for Unruptured Intracranial Aneurysm (ChTUIA) has enrolled up to 25,000 patients across 83 hospitals and is all set to refine the treatment guidelines for brain aneurysms in Chinese patients.

MONSARAZ, PORTUGAL – 30 June 2025 – The silence was broken by cheers and the snap of camera shutters as nine European high school students stepped out of a simulated Mars environment in Portugal, successfully completing the first-of-its-kind EXPLORE analog mission. From 23 to 27 June 2025, these students from Austria, Greece, and Portugal traded their everyday lives for a challenging five-day immersion in an isolated, Mars-like landscape near Monsaraz, in the wilds of the Alentejo province.