Protein clues in the blood may help children avoid diseases later in life
Peer-Reviewed Publication
Updates every hour. Last Updated: 24-Oct-2026 09:17 ET (24-Oct-2026 13:17 GMT/UTC)
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Highlights
• Integrin alpha 3 (ITGA3) protein expression was detected in approximately 85% of breast cancer specimens by immunohistochemistry.
• ITGA3 expression was significantly higher in human epidermal growth factor receptor 2 (HER2)-positive and hormone receptor(HR)-positive/HER2-negative breast cancer than in triple-negative breast cancer (TNBC).
• High ITGA3 protein expression was associated with shorter 5-year recurrence-free survival.
• ITGA3 alterations in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) cohort were associated with worse relapse-free and overall survival.
• Integrin α3β1 represents a potential prognostic biomarker and therapeutic target warranting prospective validation.