Leto Tech PBC, an Indiana startup and public benefit corporation (PBC), has launched a software system that allows users to more efficiently connect their clients with community resources. The software enables users to create a customized digital binder that can be searched several ways, including screening questions and key words, searching by name or location, and just scrolling. Users can share resource referrals with clients in a professional document or secure text.

Princeton researchers have revealed new links between high-fat diets and aggressive breast cancer, demonstrating the important role fat plays in making some cancers more invasive.

A new study develops and validates a nomogram to predict the need for continuous renal replacement therapy (CRRT) in patients with acute kidney injury (AKI) after lung transplantation. By integrating perioperative and early postoperative variables, this tool supports timely, individualized intervention, helping clinicians potentially reduce CRRT needs and improve patient outcomes in the complex post-lung transplant setting.

The diabetes drug, metformin, may mimic key benefits of exercise in prostate cancer patients, raising a molecule linked to weight and energy control even without activity. The finding suggests a new way to support metabolic health during hormone therapy, when patients often cannot exercise.

Antivirals given for chronic hepatitis B include nucleos(t)ide analog monotherapy and pegylated interferon-alpha therapy, but the safety of interferon in patients with cirrhosis has been unclear. A study in Portal Hypertension and Cirrhosis analyzed data from two large Chinese cohorts, including 920 patients with compensated cirrhosis, and found that interferon therapy was not associated with a higher risk of serious complications, supporting its use with appropriate monitoring.

Researchers from Osaka Metropolitan University and Japan System Techniques Co., Ltd. evaluated the 2019 Osaka-Higashi Line station openings using a natural experiment and health insurance claims. While the overall rail-line effect was not significant, Shigino Station, a well-connected transfer hub, showed an estimated cumulative reduction of about JPY 62,500 per medically treated person over four years, highlighting that station connectivity and local context may determinewhether new stations deliver healthcare cost benefits.