Pulmonary arterial hypertension (PAH) is a rare but life-threatening disease that progressively damages the blood vessels of the lungs and can lead to heart failure. A new review published in the Chinese Medical Journal highlights how advances in genetics, immune biology, and metabolism are transforming scientists' understanding of PAH. By bringing together recent discoveries and emerging therapies, the study suggests that targeting the disease's underlying drivers could pave the way for more effective treatments.

Artificial intelligence (AI) is emerging as a promising domain for inflammatory bowel disease (IBD) care across multiple clinical settings. In a review study, researchers highlight how AI may support disease monitoring, dysplasia detection, outcome prediction, treatment selection, and precision medicine, while emphasizing that clinical translation still requires multicenter validation, transparent models, ethical safeguards, and integration with clinician oversight before routine practice is widely adopted.

A retrospective study of 61 patients with wide-necked intracranial aneurysms found that LVIS stent-assisted coiling achieved complete initial occlusion in 80.0% of ruptured and 84.6% of unruptured aneurysms. In 14 patients analyzed with computational fluid dynamics, treatment substantially reduced aneurysm inflow and wall shear stress, with changes sustained at 6 months. Findings suggest potential hemodynamic benefits while highlighting thrombotic risks and the need for larger, prospective, comparative studies to confirm efficacy. 

As entropy returns to the scientific spotlight, an Editorial published in Intelligent Medicine proposes a new frame work arguing that critical illness may reflect a breakdown of physiological coordination, and outlines how multimodal data and interpretable AI could help test the idea.

Sepsis can leave survivors with lasting brain symptoms. Researchers report that ANXA2, a protein in the brain's immune cells, may act like an inflammation amplifier after sepsis. They designed a dual-targeted lipid carrier to bring evodiamine into the brain and microglia, easing inflammation and improving behavior and memory in mice.

Researchers identified two opposing tumor-associated macrophage states that regulate T cell interferon signaling and immunotherapy response in gastric cancer. An interferon-responsive immune niche predicts improved outcomes, while lipid-driven macrophages suppress T cell function and contribute to resistance.

While Parkinson’s disease (PD) involves complex factors, specific genetic causes often remain unknown. In Science Bulletin, a Central South University team identified H6PD as a novel PD causative gene, and found that H6PD mutations damage MAMs, the "bridges" between organelles. This "bridge failure" disables cleanup, causing mitochondrial buildup and neuron death. The study reveals a "H6PD-MAMs-Mitophagy" pathway, offering fresh targets for PD’s precision medicine.