An engineered triphasic biomaterial scaffold successfully recreated the cranial suture stem cell niche lost in craniosynostosis, a condition that causes premature fusion of skull bones. Using a pore-size-guided “bone-suture-bone” design, the scaffold maintained skeletal stem cells while supporting surrounding bone formation. In mouse models, the construct prevented re-fusion, restored craniofacial growth, and improved skull morphology. The findings may advance regenerative therapies that directly address the underlying causes of pediatric craniofacial disorders.

A study led by the Sant Pau Research Institute and Hospital de Sant Pau characterizes for the first time in vivo how a brain signal sensitive to the tau protein is distributed across the different stages of the disease.

Molecular neuroimaging identifies tau-related alterations from the early stages of the disease and opens up new avenues for understanding and treating it.

The results reveal an organized anatomical pattern that depends on the stage of the disease, with particularly consistent alterations in the globus pallidus and additional changes in other subcortical and cortical regions.

The findings, published in the European Journal of Nuclear Medicine and Molecular Imaging, provide new insights into the biological processes that, beyond the causative genetic mutation, may influence disease onset, clinical expression, and progression, while suggesting new possibilities for the development of treatments and biomarkers.

New research offers fresh hope to patients with colorectal cancer, as advances in liquid biomarker technologies are poised to reshape detection, diagnosis and treatment of the disease.

A study conducted by the Department of Obstetrics and Gynaecology at the University of Granada reveals that exposure to violence throughout a woman's life has profound and lasting effects that extend into middle age. Research published in the journal Maturitas indicates that women who have experienced violence may reach menopause up to 20 months earlier than those without such a history. This advancement in timing is specifically linked to an increased risk of premature ovarian failure (POF).

Study underlines the annual AU$7 trillion value of nature in mental health benefits, and is calling for urgent government action to expand access to nature.