This peer-reviewed Perspective synthesizes a decade of research on a surprising candidate for autism science: the laboratory Beagle. Drawing together scattered studies, the review authors argue that dogs carrying engineered changes in the Shank3 gene reproduce core human features of autism spectrum disorder, including social withdrawal, altered sensory responses, and reduced attention to the eyes of a face. The synthesis assembles, for the first time in one place, the parallels between mutant dogs and autistic people, alongside early signals that oxytocin, a psychedelic, and a third compound may soften these traits. The authors frame the dog as a complementary, ethically governed model, not a replacement for existing ones.

A comprehensive review highlights how TP53 mutations contribute to oral cancer development, treatment resistance, and poor patient outcomes. The study summarizes emerging therapeutic approaches, including mutant p53 reactivation, synthetic lethality, and immunotherapy-based strategies, providing new perspectives for precision medicine in oral cancer.A comprehensive review highlights how TP53 mutations contribute to oral cancer development, treatment resistance, and poor patient outcomes. The study summarizes emerging therapeutic approaches, including mutant p53 reactivation, synthetic lethality, and immunotherapy-based strategies, providing new perspectives for precision medicine in oral cancer.