Life-course psychosocial stress and risk of dementia and stroke in middle-aged and older adults
Peer-Reviewed Publication
Updates every hour. Last Updated: 30-May-2026 18:15 ET (30-May-2026 22:15 GMT/UTC)
UCLA Health researchers have created a comprehensive map showing how eight different genetic mutations associated with autism spectrum disorder affect early brain development, providing new insights into the ways diverse genetic causes may lead to shared features and symptoms of the disorder.
More than 135 million American adults are either living with or at risk for type 2 diabetes (T2D), elevating the need for more evidence-based dietary guidance to help this growing population achieve optimal health and reduce risks for T2D and its complications. Recently published findings from a randomized controlled trial (RCT) demonstrate that eating 6-7 ounces of beef per day does not impact risk factors for T2D, as well as other cardiometabolic health markers, in adults with prediabetes. The study, “Effects of Diets Containing Beef Compared with Poultry on Pancreatic β -Cell Function and Other Cardiometabolic Health Indicators in Males and Females with Prediabetes: A Randomized, Crossover Trial,” was published in Current Developments in Nutrition.
Targeting glucose-dependent insulinotropic polypeptide receptor (GIPR) has emerged as a promising strategy against obesity and related diseases through the “incretin effect” and regulation of other biological processes.
Empowered by the comprehensive abilities of Chemistry42, Insilico nominates ISM0676, the novel, oral available GIPR antagonist, as a clinical candidate compound (PCC) with both monotherapy and combination potential. The process from project initiation to PCC took 14 months, with less than 200 molecules synthesized and tested.
Preclinical studies have highlighted up to 31.3% body weight loss in diet-induced obese (DIO) humanized GIPR mice when co-administered with semaglutide. ISM0676 also demonstrated excellent in vivo metabolic stability, low drug-drug interaction risk, favorable safety profiles, and low predicted human efficacious dose, supporting future development.