The study, led by the Institute for Neurosciences CSIC-UMH and EPFL (Switzerland), shows that the molecule OLE helps microglia enclose and contain beta-amyloid plaques, reducing their size and toxicity.

The research, published in the journal Cell Death and Disease, could pave the way for a new strategy to combat Alzheimer’s disease by restoring the protective function of the brain’s immune system.

Conventional methods generally analyze many proteins simultaneously. The specific traits of individual protein molecules are thus often unclear. A research team led by Dr. Sarina Veit and Professor Thomas Günther-Pomorski at Ruhr University Bochum, Germany, in collaboration with researchers from Weill Cornell Medicine in New York and the University of Toronto, Canada, has developed a new microscopy platform that overcomes this limitation. The method allows the simultaneous examination of hundreds of tiny membrane spheres each with a diameter of only about 200 nanometers. Each of these synthetic membrane spheres contains just one lipid transport protein. Using this method, the researchers can conduct measurements at the level of individual protein molecules. At the same time, the platform is flexible enough to be used to examine other proteins as well. The researchers report their results in the journal Nature Structural & Molecular Biology from June 15, 2026.

A new clinical trial, led by researchers in Leicester, is investigating a new personalised treatment for patients with a rare and aggressive form of cancer, potentially giving them more time with their loved ones. 

Researchers studied the microbes associated with historical middens conserved in Greenland’s permafrost, left behind by Paleo-Inuit, ancient Norse, and early modern Inuit. These middens harbored biodiverse bacterial communities – including many unknown taxa – that were especially rich in human- and animal-associated groups. The authors concluded that microbial traces of human activities such as defecation, livestock farming, and seal hunting can linger for centuries in Arctic middens. They also found a wide range of antimicrobial resistance genes in the bacterial genomes. However, the limited outward spread of potential pathogens away from the frozen core of the middens means that they currently pose little risk to public health.